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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Amgen
Ligand
BDBM17678
(2-aminobenzimidazole, 3 | 4-[(2-{[4-chloro-3-(trif...)
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Affinity Data
Ki: 9nM ΔG°: -45.5kJ/mole
pH: 7.5 T: 2°C
Assay Description:
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
MMDB
PDB
3D Structure (crystal)
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Target
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human))
Novartis
Ligand
BDBM17678
(2-aminobenzimidazole, 3 | 4-[(2-{[4-chloro-3-(trif...)
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Affinity Data
IC50: 76nM
pH: 7.8 T: 2°C
Assay Description:
To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine/threonine-protein kinase B-raf [V600E]
(Homo sapiens (Human))
Novartis
Ligand
BDBM17678
(2-aminobenzimidazole, 3 | 4-[(2-{[4-chloro-3-(trif...)
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Affinity Data
IC50: 280nM
Assay Description:
To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI