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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
33
hits in this display
Target
Aurora kinase A
(Homo sapiens (Human))
Kasetsart University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
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Affinity Data
IC50: 4nM
Assay Description:
Inhibition of human AURKA
More data for this Ligand-Target Pair
Target Info
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Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
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Affinity Data
IC50: 4.5nM
Assay Description:
Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...
More data for this Ligand-Target Pair
Target Info
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Target
ALK tyrosine kinase receptor
(Homo sapiens (Human))
Cephalon
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Inhibition of ALK
More data for this Ligand-Target Pair
Target Info
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Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.40nM
Assay Description:
Inhibition of GST-tagged recombinant FAK (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma32...
More data for this Ligand-Target Pair
Target Info
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Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.5nM
Assay Description:
Inhibition of Focal adhesion kinase (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.5nM
Assay Description:
Inhibition of recombinant FAK domain (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.5nM
Assay Description:
Inhibition of FAK (unknown origin)
More data for this Ligand-Target Pair
Target Info
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3D Structure (crystal)
Copy BDB DOI
Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.5nM
Assay Description:
Inhibition of FAK (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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3D Structure (crystal)
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Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.80nM
Assay Description:
Inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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B.MOAD
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Copy BDB DOI
Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.20nM
Assay Description:
Inhibition of recombinant N-terminal GST-tagged human FAK (327 to 1052 residues) expressed in baculovirus expression system using TK as substrate inc...
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.30nM
Assay Description:
Inhibition of N-terminal GST-fused human truncated FAK (376 to 1052 residues) expressed in baculovirus expression system using tyrosine kinase peptid...
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
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Copy BDB DOI
Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.80nM
Assay Description:
Inhibition of human recombinant N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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MCE
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Article
PubMed
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3D Structure (crystal)
Copy BDB DOI
Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.80nM
Assay Description:
Inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
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PC sid
PDB
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In Depth
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Article
PubMed
DrugBank
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PDB
3D Structure (crystal)
Copy BDB DOI
Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.80nM
Assay Description:
Inhibition of recombinant human N-terminal His-tagged FAK cytoplasmic domain (393 to 698 residues) expressed in baculovirus infected sf9 cells assess...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
DrugBank
MCE
MMDB
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Article
PubMed
DrugBank
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3D Structure (crystal)
Copy BDB DOI
Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.90nM
Assay Description:
Inhibition of N-terminal DYKDDDD-tagged truncated FAK (376 to 1052 residues) (unknown origin) expressed in Sf21 insect cells using TK as substrate in...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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CHEMBL
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3D Structure (crystal)
Copy BDB DOI
Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7nM
Assay Description:
Inhibition of FAK (unknown origin) using Ulight-poly(Glu:Tyr)(4:1) as substrate after 1.6 hrs by TR-FRET assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Copy BDB DOI
Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7nM
Assay Description:
Inhibition of FAK (unknown origin) using ULight-poly GT as substrate after 1.6 hrs by TR-FRET assay
More data for this Ligand-Target Pair
Target Info
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Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7nM
Assay Description:
Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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CHEMBL
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Target
Insulin receptor
(Homo sapiens (Human))
Cephalon
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
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Affinity Data
IC50: 25nM
Assay Description:
Inhibition of insulin receptor
More data for this Ligand-Target Pair
Target Info
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Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 36nM
Assay Description:
Inhibition of human recombinant full length FAK incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting metho...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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CHEMBL
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MCE
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Copy BDB DOI
Target
Insulin receptor
(Homo sapiens (Human))
Cephalon
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 40nM
Assay Description:
Inhibition of recombinant insulin receptor (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
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Target
Insulin receptor
(Homo sapiens (Human))
Cephalon
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 43nM
Assay Description:
Inhibition of GST-tagged recombinant INSR (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma3...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
ALK tyrosine kinase receptor
(Homo sapiens (Human))
Cephalon
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
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Affinity Data
IC50: 50nM
Assay Description:
Inhibition of ALK by cell based assay
More data for this Ligand-Target Pair
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Target
Insulin-like growth factor 1 receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
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Affinity Data
IC50: 81nM
Assay Description:
Inhibition of GST-tagged recombinant IGFR1 (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma...
More data for this Ligand-Target Pair
Target Info
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Target
Insulin-like growth factor 1 receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
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Affinity Data
IC50: 160nM
Assay Description:
Inhibition of IGF1R (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Serine/threonine-protein kinase ULK1
(Homo sapiens (Human))
Salk Institute
US Patent
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
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Affinity Data
IC50: <200nM
Assay Description:
Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...
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Target
Serine/threonine-protein kinase ULK1
(Homo sapiens (Human))
Salk Institute
US Patent
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
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Affinity Data
IC50: <200nM
Assay Description:
ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Copy SMILES
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Affinity Data
IC50: 550nM
Assay Description:
Inhibition of GST-tagged recombinant HER1 (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma3...
More data for this Ligand-Target Pair
Target Info
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Target
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
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Affinity Data
IC50: 710nM
Assay Description:
Inhibition of GST-tagged recombinant HER2 (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma3...
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Target
Fibroblast growth factor receptor 1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
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Affinity Data
IC50: 750nM
Assay Description:
Inhibition of GST-tagged recombinant FGFR1 (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma...
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Target
Serine/threonine-protein kinase/endoribonuclease IRE1 [547-977]
(Homo sapiens (Human))
University Of Washington
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
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Affinity Data
IC50: 860nM
pH: 7.5
Assay Description:
Inhibitors (initial concentration 10 or 60 μM, three-fold serial dilutions) were incubated with IRE1α* in cleavage buffer (20 mM HEPES at p...
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Target
Platelet-derived growth factor receptor beta
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
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Affinity Data
IC50: 2.60E+3nM
Assay Description:
Inhibition of GST-tagged recombinant PDGFRbeta (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [g...
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Target
Focal adhesion kinase 1
(Homo sapiens (Human))
Dalian Medical University
Curated by
ChEMBL
Ligand
BDBM50334594
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
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Affinity Data
IC50: 5.20E+3nM
Assay Description:
Inhibition of FAK (unknown origin) by FRET-based Z'-Lyte assay
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Target Info
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KEGG
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