Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 33 hits in this display   

TargetAurora kinase A(Homo sapiens (Human))
Kasetsart University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human AURKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  5nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of GST-tagged recombinant FAK (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma32...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of Focal adhesion kinase (unknown origin)More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of recombinant FAK domain (unknown origin)More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human FAK (327 to 1052 residues) expressed in baculovirus expression system using TK as substrate inc...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of N-terminal GST-fused human truncated FAK (376 to 1052 residues) expressed in baculovirus expression system using tyrosine kinase peptid...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human recombinant N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of recombinant human N-terminal His-tagged FAK cytoplasmic domain (393 to 698 residues) expressed in baculovirus infected sf9 cells assess...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of N-terminal DYKDDDD-tagged truncated FAK (376 to 1052 residues) (unknown origin) expressed in Sf21 insect cells using TK as substrate in...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  7nMAssay Description:Inhibition of FAK (unknown origin) using Ulight-poly(Glu:Tyr)(4:1) as substrate after 1.6 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  7nMAssay Description:Inhibition of FAK (unknown origin) using ULight-poly GT as substrate after 1.6 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  7nMAssay Description:Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...More data for this Ligand-Target Pair
TargetInsulin receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  25nMAssay Description:Inhibition of insulin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human recombinant full length FAK incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting metho...More data for this Ligand-Target Pair
TargetInsulin receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant insulin receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  43nMAssay Description:Inhibition of GST-tagged recombinant INSR (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  50nMAssay Description:Inhibition of ALK by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  81nMAssay Description:Inhibition of GST-tagged recombinant IGFR1 (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  160nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Salk Institute

US Patent
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50: <200nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ULK1(Homo sapiens (Human))
Salk Institute

US Patent
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50: <200nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  550nMAssay Description:Inhibition of GST-tagged recombinant HER1 (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  710nMAssay Description:Inhibition of GST-tagged recombinant HER2 (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  750nMAssay Description:Inhibition of GST-tagged recombinant FGFR1 (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1 [547-977](Homo sapiens (Human))
University Of Washington

LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  860nMpH: 7.5Assay Description:Inhibitors (initial concentration 10 or 60 μM, three-fold serial dilutions) were incubated with IRE1α* in cleavage buffer (20 mM HEPES at p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of GST-tagged recombinant PDGFRbeta (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Dalian Medical University

Curated by ChEMBL
LigandPNGBDBM50334594(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of FAK (unknown origin) by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair