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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Sumitomo Pharma

US Patent
LigandPNGBDBM322102(N-Methyl-1-{1-(4-methylbenzyl)-5-[(2,4,5-trifluoro...)
Affinity DataKi:  2.40nMAssay Description:5-HT2A: A solution containing 50 μL of [H]-ketanserin (the final concentration: 1 nM), 2 μL of a solution of a test compound in DMSO or a s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM322102(N-Methyl-1-{1-(4-methylbenzyl)-5-[(2,4,5-trifluoro...)
Affinity DataKi:  5.5nMAssay Description:The [3H] citalopram binding was measured according to the method disclosed in Owens M. J. et al., J. Pharm. Exp. Ther., 283, 1305-1322 (1997). In spe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM322102(N-Methyl-1-{1-(4-methylbenzyl)-5-[(2,4,5-trifluoro...)
Affinity DataKi:  5.5nMAssay Description:The [3H] citalopram binding was measured according to the method disclosed in Owens M. J. et al., J. Pharm. Exp. Ther., 283, 1305-1322 (1997). In spe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM322102(N-Methyl-1-{1-(4-methylbenzyl)-5-[(2,4,5-trifluoro...)
Affinity DataKi:  5.5nMAssay Description:Specifically, a solution containing 50 μL of [3H]-citalopram (GE Healthcare) diluted with SERT buffer (50 mmol/L Tris-HCl (pH=7.4) containing 12...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Sumitomo Pharma

US Patent
LigandPNGBDBM322102(N-Methyl-1-{1-(4-methylbenzyl)-5-[(2,4,5-trifluoro...)
Affinity DataKi:  6.60nMAssay Description:5-HT2C: A solution containing 50 μL of [H]-mesulergine (GE Healthcare) diluted with 50 mmol/L Tris-HCl (pH=7.4) (the final concentration: about ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Sumitomo Pharma

US Patent
LigandPNGBDBM322102(N-Methyl-1-{1-(4-methylbenzyl)-5-[(2,4,5-trifluoro...)
Affinity DataKi:  6.60nMAssay Description:A solution of 200 μL in total was prepared by mixing 50 μL of [3H] mesulergine (manufactured by GE Healthcare) diluted with 50 mmol/L Tris-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Sumitomo Pharma

US Patent
LigandPNGBDBM322102(N-Methyl-1-{1-(4-methylbenzyl)-5-[(2,4,5-trifluoro...)
Affinity DataKi:  6.60nMAssay Description:A solution of 200 μL in total was prepared by mixing 50 μL of [3H] mesulergine (manufactured by GE Healthcare) diluted with 50 mmol/L Tris-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent