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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50301542(4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...)
Affinity DataKi:  7.90E+3nMAssay Description:Binding affinity to human mGluR5 by PDSP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50301542(4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human dopamine D2 receptor by PDSP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50301542(4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human sigma-1 receptor by PDSP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50301542(4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human histamine H1 receptor by PDSP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50301542(4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human TSPO receptor by PDSP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50301542(4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human 5-HT3 receptor by PDSP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50301542(4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity at human mGluR1 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50301542(4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4...)
Affinity DataIC50:  7.90E+3nMAssay Description:Antagonist activity at human mGluR5 receptor expressed in CHO cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed