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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50398675(CHEMBL2178126 | US8802674, 296)
Affinity DataKi:  2nMAssay Description:This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50398675(CHEMBL2178126 | US8802674, 296)
Affinity DataKi:  4nMAssay Description:Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50398675(CHEMBL2178126 | US8802674, 296)
Affinity DataIC50:  24nMAssay Description:Inhibition of autophosphorylation of LRRK2 in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed