Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetThromboxane-A synthase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50037037(5,7-Dimethyl-2-methylamino-4-pyridin-3-ylmethyl-be...)
Affinity DataIC50:  9nMAssay Description:Tested for inhibitory activity against thromboxane A2 (TXA2) synthetase in microsome of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50037037(5,7-Dimethyl-2-methylamino-4-pyridin-3-ylmethyl-be...)
Affinity DataIC50:  90nMAssay Description:Inhibitory concentration against thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Eisai

Curated by ChEMBL
LigandPNGBDBM50037037(5,7-Dimethyl-2-methylamino-4-pyridin-3-ylmethyl-be...)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against the production of thromboxane B2 (TXB2) in glycogen-induced peritoneal cells of ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50037037(5,7-Dimethyl-2-methylamino-4-pyridin-3-ylmethyl-be...)
Affinity DataIC50:  100nMAssay Description:Inhibition constant against arachidonate 5-lipoxygenase More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Eisai

Curated by ChEMBL
LigandPNGBDBM50037037(5,7-Dimethyl-2-methylamino-4-pyridin-3-ylmethyl-be...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against the production of leukotriene B4 (LTB4) in glycogen-induced peritoneal cells of ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50037037(5,7-Dimethyl-2-methylamino-4-pyridin-3-ylmethyl-be...)
Affinity DataIC50:  210nMAssay Description:Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Eisai

Curated by ChEMBL
LigandPNGBDBM50037037(5,7-Dimethyl-2-methylamino-4-pyridin-3-ylmethyl-be...)
Affinity DataIC50:  230nMAssay Description:Tested for inhibitory activity against 5-lipoxygenase in microsome of RBL-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed