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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
9
hits in this display
Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
Amgen
Ligand
BDBM35317
(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
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Affinity Data
IC50: 0.270nM
Assay Description:
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
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Article
PubMed
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Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
Amgen
Ligand
BDBM35317
(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
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Copy InChI
Affinity Data
IC50: 0.300nM
Assay Description:
Inhibition of Lck by HTRF kinase assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM35317
(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
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Affinity Data
IC50: 1nM
Assay Description:
Inhibition of KDR by HTRF kinase assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM35317
(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1nM
pH: 7.5 T: 2°C
Assay Description:
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine/threonine-protein kinase B-raf [V600E]
(Homo sapiens (Human))
Amgen
Ligand
BDBM35317
(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
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Affinity Data
IC50: 1.70nM EC50: 27nM
pH: 7.0 T: 2°C
Assay Description:
The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Angiopoietin-1 receptor
(Homo sapiens (Human))
Amgen
Ligand
BDBM35317
(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
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Affinity Data
IC50: 1.80nM
Assay Description:
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM35317
(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
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Affinity Data
IC50: 2nM
Assay Description:
Inhibition of p38-alpha by HTRF kinase assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM35317
(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.5nM
pH: 7.5 T: 2°C
Assay Description:
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tyrosine-protein kinase JAK3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM35317
(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
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Copy InChI
Affinity Data
IC50: 16nM
Assay Description:
Inhibition of Jak3 by HTRF kinase assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI