Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 9 hits in this display   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  0.270nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  1nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Amgen

LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  1.70nM EC50:  27nMpH: 7.0 T: 2°CAssay Description:The in vitro kinase activities of wild type or mutants were determined by measuring phosphorylation of biotinylated-MEK protein using Perkin-Elmer s ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  1.80nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  3.5nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Jak3 by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed