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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
16
hits in this display
Target
Angiopoietin-1 receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
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Affinity Data
IC50: 16nM
Assay Description:
Inhibition of Tie2 after 90 mins by HTRF assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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Details
Article
PubMed
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Target
Angiopoietin-1 receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
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Copy InChI
Affinity Data
IC50: 33nM
Assay Description:
Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrs
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
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Affinity Data
IC50: 47nM
Assay Description:
Inhibition of p38alpha by radioactive filtration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
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Affinity Data
IC50: 146nM
Assay Description:
Inhibition of Lck by radioactive filtration assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 194nM
Assay Description:
Inhibition of p38alpha in THP1 cells assessed as TNFalpha levels
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
Inhibition of KDR after 90 mins by HTRF assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tyrosine-protein kinase JAK2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
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Affinity Data
IC50: 1.75E+3nM
Assay Description:
Inhibition of Jak2 by radioactive filtration assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
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Target
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
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Affinity Data
IC50: 2.20E+3nM
Assay Description:
Inhibition of Src by radioactive filtration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.30E+3nM
Assay Description:
Inhibition of KDR autophosphorylation in EA.hy926 cells after 2.5 hrs
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
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Affinity Data
IC50: 1.78E+4nM
Assay Description:
Inhibition of cKit by radioactive filtration assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Hepatocyte growth factor receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of cMet by radioactive filtration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Tyrosine-protein kinase ZAP-70
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of Zap70 by radioactive filtration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of EGFR by radioactive filtration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Insulin-like growth factor 1 receptor
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of IGFR1 by radioactive filtration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tyrosine-protein kinase BTK
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of BTK by radioactive filtration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase 10
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50207854
(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.00E+4nM
Assay Description:
Inhibition of JNK3 by radioactive filtration assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI