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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 16 hits in this display   

TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  33nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  47nMAssay Description:Inhibition of p38alpha by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  146nMAssay Description:Inhibition of Lck by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  194nMAssay Description:Inhibition of p38alpha in THP1 cells assessed as TNFalpha levelsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of Jak2 by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of Src by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of KDR autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  1.78E+4nMAssay Description:Inhibition of cKit by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of cMet by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of Zap70 by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of EGFR by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of IGFR1 by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of BTK by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50207854(CHEMBL246356 | N-(4-methyl-3-(3-(4-(methylamino)-1...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of JNK3 by radioactive filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed