Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL

LigandBDBM50253101(7-(1-Isopropylphthalazin-6-yl)-N,6-dimethylbenzo[d...)Copy SMILESCopy InChI

Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL

LigandBDBM50253101(7-(1-Isopropylphthalazin-6-yl)-N,6-dimethylbenzo[d...)Copy SMILESCopy InChI

Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI