Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene

Curated by ChEMBL

LigandBDBM50092768(CHEMBL3586403)Copy SMILESCopy InChI

Affinity DataIC50:  103nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetFKBP12A/mTOR(Homo sapiens (Human))
Celgene

Curated by ChEMBL

LigandBDBM50092768(CHEMBL3586403)Copy SMILESCopy InChI

Affinity DataIC50:  340nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of S6 phosphorylation after 1 hrMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Celgene

Curated by ChEMBL

LigandBDBM50092768(CHEMBL3586403)Copy SMILESCopy InChI

Affinity DataIC50:  1.64E+4nMAssay Description:Inhibition of PI3K-alpha (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI