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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50198702
((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
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Affinity Data
Ki: 1.70nM
Assay Description:
Displacement of [3H]ABP688 from human mGluR5 receptor expressed in L (tk-) cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50198702
((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.80nM
Assay Description:
Displacement of [3H]ABP688 from mGluR5 in rat brain membrane
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50198702
((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.5nM
Assay Description:
Displacement of [3H]M-MPEP from human mGluR5 receptor expressed in L (tk-) cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50198702
((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.40nM
Assay Description:
Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50198702
((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.30nM
Assay Description:
Activity at human recombinant mGluR5 expressed in L(tk-) cells assessed as inhibition of glutamate-induced calcium release
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50198702
((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.40nM
Assay Description:
Activity at human recombinant mGluR5 expressed in L(tk-) cells assessed as inhibition of quisqualate-induced phosphoinositol accumulation
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50198702
((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7nM
Assay Description:
Displacement of [3H]M-MPEP from human mGluR5 receptor expressed in L (tk-) cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat))
Novartis Institutes For Biomedical Research
Curated by
ChEMBL
Ligand
BDBM50198702
((E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-en...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 2.30nM
Assay Description:
Binding affinity at mGluR5 in rat brain membrane
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI