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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetTransporter(Rattus norvegicus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296((3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-...)
Affinity DataKi:  242nMAssay Description:Ability to inhibit high affinity uptake of norepinephrine transporter into the nerve endings of rat synaptosomes using [3H]NE radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296((3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-...)
Affinity DataKi:  396nMAssay Description:Displacement of [3H]NE from Norepinephrine transporter of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296((3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-...)
Affinity DataKi:  930nMAssay Description:Displacement of [3H]5-HT from serotonin transporter of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296((3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-...)
Affinity DataKi:  1.77E+3nMAssay Description:Displacement of [3H]mazindol binding to dopamine transporter (DAT) in rat synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296((3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-...)
Affinity DataKi:  2.01E+3nMAssay Description:Displacement of [3H]WIN-35248 from dopamine transporter (DAT) of rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296((3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-...)
Affinity DataKi:  2.89E+3nMAssay Description:Inhibition of high affinity DA uptake into rat synaptosomes using [3H]DAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296((3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-...)
Affinity DataKi:  2.93E+3nMAssay Description:Inhibition of high affinity uptake of [3H]DA using rat nerve endings obtained from brain regions enriched in DAT.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296((3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of high affinity serotonin uptake into rat synaptosomes using [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296((3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-...)
Affinity DataIC50:  1.36E+3nMAssay Description:Ability to displace [3H]WIN-35428 binding to dopamine transporter from rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50099296((3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-...)
Affinity DataIC50:  5.09E+3nMAssay Description:Inhibition of high-affinity uptake of [3H]dopamine at dopamine transporter into rat striatal nerve endings (synaptosomes)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed