Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 19 hits in this display
BDBM236789(US9388149, 20 | US9580412, Example 20)
BDBM236789(US9388149, 20 | US9580412, Example 20)
IC50: 8.80nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
BDBM291177(US9580412, Example 6 | US9580412, Example 7 | meth...)
IC50: 9.70nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
BDBM236789(US9388149, 20 | US9580412, Example 20)
IC50: 21nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
BDBM236789(US9388149, 20 | US9580412, Example 20)
BDBM236806(US9388149, 6 | US9388149, 7 (Diastereoisomer 1))
IC50: 30nMT: 2°CAssay Description:PathHunter HEK293-CXCR2 or U2OS hCXCR1 β-arrestin cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
BDBM291177(US9580412, Example 6 | US9580412, Example 7 | meth...)
IC50: 30nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
BDBM291177(US9580412, Example 6 | US9580412, Example 7 | meth...)
IC50: 37nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
BDBM236789(US9388149, 20 | US9580412, Example 20)
IC50: 43nMT: 2°CAssay Description:PathHunter HEK293-CXCR2 or U2OS hCXCR1 β-arrestin cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
BDBM236789(US9388149, 20 | US9580412, Example 20)
IC50: 43nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
BDBM236806(US9388149, 6 | US9388149, 7 (Diastereoisomer 1))
IC50: 86nMT: 2°CAssay Description:PathHunter HEK293-CXCR2 or U2OS hCXCR1 β-arrestin cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
BDBM291177(US9580412, Example 6 | US9580412, Example 7 | meth...)
IC50: 86nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
BDBM291177(US9580412, Example 6 | US9580412, Example 7 | meth...)
IC50: 108nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
BDBM236806(US9388149, 6 | US9388149, 7 (Diastereoisomer 1))
IC50: 108nMT: 2°CAssay Description:PathHunter HEK293-CXCR2 or U2OS hCXCR1 β-arrestin cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
BDBM291177(US9580412, Example 6 | US9580412, Example 7 | meth...)
IC50: 140nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
BDBM291177(US9580412, Example 6 | US9580412, Example 7 | meth...)
IC50: 171nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
BDBM236789(US9388149, 20 | US9580412, Example 20)
IC50: 180nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
BDBM236806(US9388149, 6 | US9388149, 7 (Diastereoisomer 1))
IC50: 859nMT: 2°CAssay Description:PathHunter HEK293-CXCR2 or U2OS hCXCR1 β-arrestin cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
BDBM291177(US9580412, Example 6 | US9580412, Example 7 | meth...)
IC50: 859nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair