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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
28
hits in this display
Target
Transporter
(Rattus norvegicus)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
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Affinity Data
Ki: 4.40nM
Assay Description:
Displacement of [3H]nisoxetine from norepinephrine transporter (NET) of rat cerebral cortex
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Transporter
(Rattus norvegicus)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.40nM
Assay Description:
Displacement of [3H]nisoxetine from norepinephrine transporter (NET) of rat cerebral cortex
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
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Target
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human))
Emory University
Curated by
ChEMBL
Ligand
BDBM50210952
((1R,2S,3R,5R)-methyl 3-p-tolyl-8-aza-bicyclo[3.2.1...)
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Affinity Data
Ki: 4.88nM
Assay Description:
Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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Article
PubMed
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Target
Transporter
(Rattus norvegicus)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.20nM
Assay Description:
Inhibition of 0.5 nM [3H]nisoxetine binding toNorepinephrine transporter
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
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GoogleScholar
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CHEMBL
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Article
PubMed
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Target
Transporter
(Rattus norvegicus)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.20nM
Assay Description:
Inhibition of 0.5 nM [3H]nisoxetine binding to Norepinephrine transporter
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
Details
Article
PubMed
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Target
Transporter
(Rattus norvegicus)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50127385
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.40nM
Assay Description:
Inhibition of [3H]nisoxetine binding at norepinephrine transporter was determined
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
Emory University
Curated by
ChEMBL
Ligand
BDBM50210952
((1R,2S,3R,5R)-methyl 3-p-tolyl-8-aza-bicyclo[3.2.1...)
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Affinity Data
Ki: 11.5nM
Assay Description:
Displacement of [125I]RTI55 from human DAT expressed in HEK293 cells
More data for this Ligand-Target Pair
Target Info
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
Ligand Info
CHEMBL
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PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 12nM
Assay Description:
Displacement of [3H]paroxetine from serotonin transporter (5-HT) of rat cerebral cortex
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 12nM
Assay Description:
Displacement of [3H]paroxetine from serotonin transporter (5-HT) of rat cerebral cortex
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 46nM
Assay Description:
Inhibition of 0.2 nM [3H]paroxetine binding to Serotonin transporter
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 46nM
Assay Description:
Inhibition of 0.2 nM [3H]paroxetine binding to Serotonin transporter
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50127385
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic ...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 46nM
Assay Description:
Inhibition of [3H]paroxetine binding at serotonin transporter was determined
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Emory University
Curated by
ChEMBL
Ligand
BDBM50210952
((1R,2S,3R,5R)-methyl 3-p-tolyl-8-aza-bicyclo[3.2.1...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 136nM
Assay Description:
Displacement of [3H]citalopram from human SERT expressed in HEK293 cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.840nM
Assay Description:
Inhibition of [3H]WIN-35428 binding to rat striatal dopamine transporter
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.840nM
Assay Description:
Inhibition of [3H]WIN-35428 binding to rat striatal dopamine transporter
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Transporter
(Rattus norvegicus)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9nM
Assay Description:
Inhibition of 0.2 nM [3H]paroxetine binding to Serotonin transporter
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Transporter
(Rattus norvegicus)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9nM
Assay Description:
Inhibition of [3H]nisoxetine binding to rat cerebral cortex norepinephrine transporter
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Transporter
(Rattus norvegicus)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9nM
Assay Description:
Inhibition of 0.5 nM [3H]nisoxetine binding to Norepinephrine transporter
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Transporter
(Rattus norvegicus)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9nM
Assay Description:
Inhibition of [3H]nisoxetine binding to rat cerebral cortex norepinephrine transporter
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Transporter
(Rattus norvegicus)
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50127385
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9nM
Assay Description:
Inhibition of [3H]nisoxetine binding at norepinephrine transporter
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 33.6nM
Assay Description:
Displacement of 0.5 nM [3H]WIN-35248 from Dopamine transporter
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50127385
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 34nM
Assay Description:
Inhibition of [3H]WIN-35428 binding at dopamine transporter was determined
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 34nM
Assay Description:
Displacement of 0.5 nM [3H]WIN-35248 from Dopamine transporter
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 135nM
Assay Description:
Inhibition of [3H]paroxetine binding to rat cortex serotonin transporter
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 135nM
Assay Description:
Inhibition of [3H]paroxetine binding to rat cortex serotonin transporter
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 500nM
Assay Description:
Inhibition of 0.5 nM [3H]nisoxetine binding to Norepinephrine transporter
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50127385
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 500nM
Assay Description:
Inhibition of [3H]paroxetine binding at serotonin transporter was determined
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Research Triangle Institute
Curated by
ChEMBL
Ligand
BDBM50093781
(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 500nM
Assay Description:
Inhibition of 0.2 nM [3H]paroxetine binding to Serotonin transporter
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI