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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 28 hits in this display   

TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]nisoxetine from norepinephrine transporter (NET) of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]nisoxetine from norepinephrine transporter (NET) of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50210952((1R,2S,3R,5R)-methyl 3-p-tolyl-8-aza-bicyclo[3.2.1...)
Affinity DataKi:  4.88nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataKi:  5.20nMAssay Description:Inhibition of 0.5 nM [3H]nisoxetine binding toNorepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataKi:  5.20nMAssay Description:Inhibition of 0.5 nM [3H]nisoxetine binding to Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127385(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic ...)
Affinity DataKi:  5.40nMAssay Description:Inhibition of [3H]nisoxetine binding at norepinephrine transporter was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50210952((1R,2S,3R,5R)-methyl 3-p-tolyl-8-aza-bicyclo[3.2.1...)
Affinity DataKi:  11.5nMAssay Description:Displacement of [125I]RTI55 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter (5-HT) of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter (5-HT) of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataKi:  46nMAssay Description:Inhibition of 0.2 nM [3H]paroxetine binding to Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataKi:  46nMAssay Description:Inhibition of 0.2 nM [3H]paroxetine binding to Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127385(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic ...)
Affinity DataKi:  46nMAssay Description:Inhibition of [3H]paroxetine binding at serotonin transporter was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50210952((1R,2S,3R,5R)-methyl 3-p-tolyl-8-aza-bicyclo[3.2.1...)
Affinity DataKi:  136nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of [3H]WIN-35428 binding to rat striatal dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of [3H]WIN-35428 binding to rat striatal dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataIC50:  9nMAssay Description:Inhibition of 0.2 nM [3H]paroxetine binding to Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataIC50:  9nMAssay Description:Inhibition of [3H]nisoxetine binding to rat cerebral cortex norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataIC50:  9nMAssay Description:Inhibition of 0.5 nM [3H]nisoxetine binding to Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataIC50:  9nMAssay Description:Inhibition of [3H]nisoxetine binding to rat cerebral cortex norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127385(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic ...)
Affinity DataIC50:  9nMAssay Description:Inhibition of [3H]nisoxetine binding at norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataIC50:  33.6nMAssay Description:Displacement of 0.5 nM [3H]WIN-35248 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127385(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic ...)
Affinity DataIC50:  34nMAssay Description:Inhibition of [3H]WIN-35428 binding at dopamine transporter was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataIC50:  34nMAssay Description:Displacement of 0.5 nM [3H]WIN-35248 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataIC50:  135nMAssay Description:Inhibition of [3H]paroxetine binding to rat cortex serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataIC50:  135nMAssay Description:Inhibition of [3H]paroxetine binding to rat cortex serotonin transporter More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataIC50:  500nMAssay Description:Inhibition of 0.5 nM [3H]nisoxetine binding to Norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127385(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic ...)
Affinity DataIC50:  500nMAssay Description:Inhibition of [3H]paroxetine binding at serotonin transporter was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50093781(3-p-Tolyl-8-aza-bicyclo[3.2.1]octane | 3-p-Tolyl-8...)
Affinity DataIC50:  500nMAssay Description:Inhibition of 0.2 nM [3H]paroxetine binding to Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed