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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
9
hits in this display
Target
AP2-associated protein kinase 1
(Mus musculus)
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM311380
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
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Affinity Data
Ki: 0.110nM
Assay Description:
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
PubMed
Copy BDB DOI
Target
AP2-associated protein kinase 1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM311380
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.10nM
Assay Description:
Inhibition of bacterially expressed GST-Xa-tagged human AAK1 using 5-FAM-labelled Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incubated for 3 hrs...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
PubMed
Copy BDB DOI
Target
AP2-associated protein kinase 1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM311380
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.40nM
Assay Description:
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
AP2-associated protein kinase 1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM311380
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.40nM
Assay Description:
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
AP2-associated protein kinase 1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM311380
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.40nM
Assay Description:
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
AP2-associated protein kinase 1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM311380
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.40nM
Assay Description:
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
AP2-associated protein kinase 1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM311380
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.40nM
Assay Description:
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
AP2-associated protein kinase 1
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM311380
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.40nM
Assay Description:
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 Cl prepared from 15 μl additions of enzyme and substrates (...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by
ChEMBL
Ligand
BDBM311380
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of CYP3A4 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
PubMed
Copy BDB DOI