Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 7 hits in this display
BDBM113298(US10336717, Compound 76 | US8633212, 76 | US921215...)
BDBM113298(US10336717, Compound 76 | US8633212, 76 | US921215...)
BDBM113298(US10336717, Compound 76 | US8633212, 76 | US921215...)
BDBM195392(US10336717, Compound 478 | US9212153, 478,Ex. 409)
IC50: 2.20nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
BDBM195392(US10336717, Compound 478 | US9212153, 478,Ex. 409)
IC50: 2.20nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity using commercially available substrate HiLyte Fluor 488...More data for this Ligand-Target Pair
BDBM195533(US10336717, Compound 477 | US9212153, 477,Ex. 409)
IC50: 694nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity using commercially available substrate HiLyte Fluor 488...More data for this Ligand-Target Pair
BDBM195533(US10336717, Compound 477 | US9212153, 477,Ex. 409)
IC50: 694nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair