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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetBeta-secretase 1 [1-458](Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195484(US9212153, 332,Ex. 281)
Affinity DataIC50:  34.9nMpH: 4.4Assay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM259485(US9526727, Comparison Example Table 2, 2''-amino-4...)
Affinity DataIC50:  35nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM259485(US9526727, Comparison Example Table 2, 2''-amino-4...)
Affinity DataIC50:  1.00E+4nMpH: 7.4 T: 2°CAssay Description:Cells were superfused with a bath solution containing (mM): NaCl (137), KCl (4.0), MgCl2 (1.0), CaCl2 (1.8), Glucose (10), HEPES (10), pH 7.4 with Na...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent