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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 16 hits in this display   

TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataKi:  14nMAssay Description:Inhibition of human MMP-14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of human MMP-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of human MMP13 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of human MMP9 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human MMP8 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human MMP14 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human MMP3 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human MMP7 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MMP1 expressed in human HT-1080 cells assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluoromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed