Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetAurora kinase B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

LigandBDBM50352325(CHEMBL1822651)Copy SMILESCopy InChI

Affinity DataIC50:  49nMAssay Description:Inhibition of Aurora B kinase assessed as reduction in histone H3 phosphorylation in human HCT116 cellsMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetAurora kinase A(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

LigandBDBM50352325(CHEMBL1822651)Copy SMILESCopy InChI

Affinity DataKd:  5nMAssay Description:Binding affinity to Aurora A kinase catalytic domain by competitive binding assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetAurora kinase B(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

LigandBDBM50352325(CHEMBL1822651)Copy SMILESCopy InChI

Affinity DataKd:  2nMAssay Description:Binding affinity to Aurora B kinase catalytic domain by competitive binding assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI