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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Bayreuth

Curated by ChEMBL
LigandPNGBDBM50195543(CHEMBL2236206)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of BCRP in human MCF7/Topo cells assessed as mitoxantrone accumulation preincubated for 10 mins followed by mitoxantrone addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrophozoite cysteine proteinase(Plasmodium falciparum)TBA
LigandPNGBDBM50195543(CHEMBL2236206)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of Plasmodium falciparum W2 cysteine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTrophozoite cysteine proteinase(Plasmodium falciparum)TBA
LigandPNGBDBM50195543(CHEMBL2236206)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of Plasmodium falciparum W2 cysteine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
University Bayreuth

Curated by ChEMBL
LigandPNGBDBM50195543(CHEMBL2236206)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of P-gp in human KB-V1/Vbl cells assessed as calcein-AM accumulation preincubated for 15 mins followed by calcein-AM addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed