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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
19
hits in this display
Target
Tyrosine-protein kinase ITK/TSK
(Homo sapiens (Human))
University Of California San Francisco
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
Ki: 16nM
Assay Description:
Inhibition of ITK
More data for this Ligand-Target Pair
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3D Structure (crystal)
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Target
Tyrosine-protein kinase ITK/TSK
(Homo sapiens (Human))
University Of California San Francisco
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: 10nM
Assay Description:
Inhibition of human ITK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISA
More data for this Ligand-Target Pair
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Target
Tyrosine-protein kinase ITK/TSK
(Homo sapiens (Human))
University Of California San Francisco
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: 19nM
Assay Description:
Inhibition of Itk
More data for this Ligand-Target Pair
Target Info
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Target
Insulin receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of Insulin receptor
More data for this Ligand-Target Pair
Target Info
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Target
Tyrosine-protein kinase Fyn
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: 1.10E+3nM
Assay Description:
Inhibition of Fyn
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Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: 2.40E+3nM
Assay Description:
Inhibition of LCK
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Target
Tyrosine-protein kinase BTK
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: 4.10E+3nM
Assay Description:
Inhibition of Btk
More data for this Ligand-Target Pair
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Target
Tyrosine-protein kinase TXK
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: 1.10E+4nM
Assay Description:
Inhibition of Txk
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Target
Tyrosine-protein kinase Tec
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: 1.70E+4nM
Assay Description:
Inhibition of Tec
More data for this Ligand-Target Pair
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Target
O94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: 2.40E+4nM
Assay Description:
Inhibition of PKC
More data for this Ligand-Target Pair
Target Info
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Target
Cyclin-dependent kinase 2
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: 2.90E+4nM
Assay Description:
Inhibition of Cdk2
More data for this Ligand-Target Pair
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: 3.60E+4nM
Assay Description:
Inhibition of GSK3-beta
More data for this Ligand-Target Pair
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Target
Tyrosine-protein kinase SYK
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of Syk
More data for this Ligand-Target Pair
Target Info
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of EGFR
More data for this Ligand-Target Pair
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Target
Tyrosine-protein kinase ZAP-70
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of ZAP70
More data for this Ligand-Target Pair
Target Info
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Target
cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of PKA
More data for this Ligand-Target Pair
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Target
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of Akt1
More data for this Ligand-Target Pair
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Target
Mitogen-activated protein kinase 3
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of ERK1
More data for this Ligand-Target Pair
Target Info
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Target
Inhibitor of nuclear factor kappa-B kinase subunit beta
(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50186460
(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of IKK-beta
More data for this Ligand-Target Pair
Target Info
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