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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50344232
(1-cyclopropyl-N-((6-(4-fluoro-2-methoxyphenyl)pyra...)
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Affinity Data
Ki: 27nM
Assay Description:
Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membrane
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Astrazeneca Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50344232
(1-cyclopropyl-N-((6-(4-fluoro-2-methoxyphenyl)pyra...)
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Affinity Data
IC50: 380nM
Assay Description:
Iinhibition of CYP2D6
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human))
Astrazeneca Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50344232
(1-cyclopropyl-N-((6-(4-fluoro-2-methoxyphenyl)pyra...)
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Copy InChI
Affinity Data
IC50: 508nM
Assay Description:
Antagonist activity at human NR2B expressed in HEK293 cells assessed as glutamate-induced changes in intracellular calcium concentration
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Astrazeneca Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50344232
(1-cyclopropyl-N-((6-(4-fluoro-2-methoxyphenyl)pyra...)
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Affinity Data
IC50: 1.89E+3nM
Assay Description:
Inhibition of human ERG expressed in CHOK1 cells electrophysiology study
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Astrazeneca Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50344232
(1-cyclopropyl-N-((6-(4-fluoro-2-methoxyphenyl)pyra...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Iinhibition of CYP3A4
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI