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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344232(1-cyclopropyl-N-((6-(4-fluoro-2-methoxyphenyl)pyra...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]CP101606 from NR2B in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344232(1-cyclopropyl-N-((6-(4-fluoro-2-methoxyphenyl)pyra...)
Affinity DataIC50:  380nMAssay Description:Iinhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344232(1-cyclopropyl-N-((6-(4-fluoro-2-methoxyphenyl)pyra...)
Affinity DataIC50:  508nMAssay Description:Antagonist activity at human NR2B expressed in HEK293 cells assessed as glutamate-induced changes in intracellular calcium concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344232(1-cyclopropyl-N-((6-(4-fluoro-2-methoxyphenyl)pyra...)
Affinity DataIC50:  1.89E+3nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells electrophysiology studyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50344232(1-cyclopropyl-N-((6-(4-fluoro-2-methoxyphenyl)pyra...)
Affinity DataIC50: >2.00E+4nMAssay Description:Iinhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed