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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
29
hits in this display
Target
Aldehyde oxidase 1
(Oryctolagus cuniculus)
Pfizer
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
Ki: 60nM
Assay Description:
Inhibition of rabbit aldehyde oxidase
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
University Of Leicester
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
Ki: 7.50E+3nM
Assay Description:
Binding affinity for cytochrome P450 2D6
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Tcg Lifesciences
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: 209nM
Assay Description:
Inhibition of human ERG
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Tcg Lifesciences
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: 210nM
Assay Description:
Inhibition of human ERG potassium channel
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Target
Nuclear receptor coactivator 3
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: >443nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...
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Target
DNA topoisomerase 2-alpha/2-beta
(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: 1.00E+3nM
Assay Description:
In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenation
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Target
DNA topoisomerase 2-beta
(Homo sapiens (Human))
Cairo University
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: 2.76E+3nM
Assay Description:
Inhibition of human topoisomerase-2B after 2 hrs by ELISA
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Target
Aldehyde oxidase
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: 3.20E+3nM
Assay Description:
Inhibition of human aldehyde oxidase
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Target
Solute carrier family 22 member 1
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: 5.00E+3nM
Assay Description:
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy
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Target
Aldehyde oxidase 1
(Rattus norvegicus)
Pfizer
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: 6.40E+3nM
Assay Description:
Inhibition of rat aldehyde oxidase
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Target
Aldehyde oxidase 1
(Rattus norvegicus)
Pfizer
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: 6.40E+3nM
Assay Description:
Inhibition of rat aldehyde oxidase
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Target
ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: 7.43E+3nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
DNA topoisomerase 2-alpha
(Homo sapiens (Human))
Universidad Nacional AutóNoma De MéXico
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: 9.94E+3nM
Assay Description:
Inhibition of human DNA topoisomerase 2-mediated Crithidia fasciculata kDNA decatenation using ethidium bromide staining by agarose gel electrophores...
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
University Of Leicester
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: 1.02E+4nM
Assay Description:
Inhibitory concentration against cytochrome P450 2D6
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
University Of Leicester
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: 1.05E+4nM
Assay Description:
Inhibitory concentration against cytochrome P450 2D6
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Target
DNA topoisomerase 2-alpha
(Homo sapiens (Human))
Universidad Nacional AutóNoma De MéXico
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: 1.60E+4nM
Assay Description:
Inhibition of human topoisomerase 2alpha using supercoiled pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence based microplate reade...
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Target
Tegument protein VP16
(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: >3.59E+4nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...
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Target
Nuclear receptor coactivator 1
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: >3.59E+4nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...
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Target
ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Target
DNA topoisomerase 2-alpha/2-beta
(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
EC50: 720nM
Assay Description:
In vitro inhibitior of human DNA topoisomerase II from HeLa cells.
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Target
DNA topoisomerase 2-alpha/2-beta
(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
EC50: 720nM
Assay Description:
Tested for inhibitory activity against Topoisomerase II isolated from HeLa cells by using SDS-K+ precipitation method
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Target
DNA topoisomerase 2-alpha/2-beta
(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
EC50: 720nM
Assay Description:
Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assay
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Target
DNA topoisomerase 2-alpha/2-beta
(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
EC50: 720nM
Assay Description:
Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation method
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Target
DNA topoisomerase 2-alpha/2-beta
(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
EC50: 720nM
Assay Description:
Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa cell topoisomerase II.
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Target
DNA topoisomerase 2-alpha/2-beta
(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
EC50: 720nM
Assay Description:
Inhibitory activity against HeLa cell Topoisomerase II
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Target
DNA topoisomerase 2-beta
(Homo sapiens (Human))
Cairo University
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
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Affinity Data
EC50: 1.10E+4nM
Assay Description:
Inhibition of calf thymus DNA/ethidium bromide complex formation.
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Target
DNA topoisomerase 2-alpha/2-beta
(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research
Curated by
ChEMBL
Ligand
BDBM87351
(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
Copy SMILES
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Affinity Data
EC50: 720nM
Assay Description:
Inhibition of topoisomerase II purified from HeLa cells
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