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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Université
Curated by
ChEMBL
Ligand
BDBM50156592
(1-(4-methanesulfonylphenyl)-3-[(3,5-dimethoxy)phen...)
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Affinity Data
IC50: 870nM
Assay Description:
Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Université
Curated by
ChEMBL
Ligand
BDBM50156592
(1-(4-methanesulfonylphenyl)-3-[(3,5-dimethoxy)phen...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
Université
Curated by
ChEMBL
Ligand
BDBM50156592
(1-(4-methanesulfonylphenyl)-3-[(3,5-dimethoxy)phen...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.51E+4nM
Assay Description:
Inhibition of COX1 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI