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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Kelch-like ECH-associated protein 1
(Homo sapiens (Human))
Astex Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM304728
(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
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Affinity Data
IC50: 42nM
Assay Description:
Displacement of 5'-TAMRA-labelled NRF2 peptide from human N-terminal His6-tagged KEAP1 Kelch domain (321 to 609 residues) expressed in baculovirus in...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Kelch-like ECH-associated protein 1 [321-609]
(Homo sapiens (Human))
Glaxosmithkline
US Patent
Ligand
BDBM304728
(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
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Affinity Data
IC50: 55nM
Assay Description:
100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Nuclear factor erythroid 2-related factor 2
(Homo sapiens (Human))
Astex Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM304728
(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
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Affinity Data
EC50: 760nM
Assay Description:
Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assay
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Nuclear factor erythroid 2-related factor 2
(Homo sapiens (Human))
Astex Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM304728
(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 5.50E+3nM
Assay Description:
NAD(P)H:quinone oxidoreductase 1 (NQO1), also called DT diaphorase, is a homodimeric FAD-containing enzyme that catalyzes obligatory NAD(P)H-dependen...
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI