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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
59
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Target
Cysteinyl leukotriene receptor 1
(Homo sapiens (Human))
University of California Irvine
Curated by
PDSP K
i
Database
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
Ki: 0.260nM
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Ici Pharmaceuticals Group
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
Ki: 0.300nM
Assay Description:
Displacement of [3H]-LTD4 on guinea pig lung parenchymal membranes
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Ici Pharmaceuticals Group
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
Ki: 0.300nM
Assay Description:
Displacement of [3H]LTD4 from cysteinyl leukotriene receptor 1 in Hartley guinea pig parenchymal membrane after 30 mins by liquid scintillation count...
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Ici Pharmaceuticals Group
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
Ki: 0.300nM
Assay Description:
Compound was evaluated for its ability to displace [3H]-LTD4 from Cysteinyl leukotriene D4 receptor in guinea pig lung membranes
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Ici Pharmaceuticals Group
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
Ki: 0.300nM
Assay Description:
Binding affinity of the compound towards Cysteinyl leukotriene D4 receptor (cysLT1) was measured by the displacement of [3H]-LTD4 radioligand
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Ici Pharmaceuticals Group
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
Ki: 0.340nM
Assay Description:
Inhibition constant for displacement of [3H]-LTD4 on guinea pig lung parenchymal membranes
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Target
Cysteinyl leukotriene receptor 1/2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
Ki: 2nM
Assay Description:
Ability to antagonize LTD4 receptors isolated from guinea pig lung membranes
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Ici Pharmaceuticals Group
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
Ki: 2nM
Assay Description:
Compound was evaluated in vitro for the binding of cysLT1 receptor to guinea pig lung membranes.
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Ici Pharmaceuticals Group
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
Ki: 2nM
Assay Description:
Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Ici Pharmaceuticals Group
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
Ki: 2.30nM
Assay Description:
Displacement of [3H]-leukotriene D4 (LTD4) from receptor in guinea pig lung membranes
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Target
Cysteinyl leukotriene receptor 2
(Homo sapiens (Human))
University of California Irvine
Curated by
PDSP K
i
Database
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
Ki: 1.00E+3nM
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Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Astrazeneca R&D
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
Ki: 2.50E+3nM
Assay Description:
Binding affinity towards cytochrome P450 2C9
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Target
Leukotriene B4 receptor 1
(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
Ki: 7.12E+3nM
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Target
Leukotriene B4 receptor 2
(Homo sapiens (Human))
University of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
Ki: 7.40E+3nM
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Target
Leukotriene B4 receptor 2
(Homo sapiens (Human))
University of Virginia
Curated by
PDSP K
i
Database
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
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Target
Platelet-activating factor receptor
(Cavia porcellus)
TBA
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
Ki: >5.00E+4nM
Assay Description:
Displacement of [3H]-ligand from platelet activating factor (PAF) receptor in rabbit platelets
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Target
Cysteinyl leukotriene receptor 1
(Homo sapiens (Human))
University of California Irvine
Curated by
PDSP K
i
Database
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
IC50: 0.260nM
Assay Description:
Antagonist activity at human CysLT1 receptor
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Ici Pharmaceuticals Group
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.440nM
Assay Description:
Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes
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Target
Cysteinyl leukotriene receptor 1
(Homo sapiens (Human))
University of California Irvine
Curated by
PDSP K
i
Database
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
IC50: 1.80nM
Assay Description:
Inhibition of cysteinyl leukotriene receptor 1 (unknown origin) expressed in HEK293 cell membranes after 45 mins by scintillation spectrometry
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Target
Cysteinyl leukotriene receptor 1
(Homo sapiens (Human))
University of California Irvine
Curated by
PDSP K
i
Database
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
IC50: 1.90nM
Assay Description:
Antagonist activity at human CysLT1
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Ici Pharmaceuticals Group
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
IC50: 2nM
Assay Description:
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay
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Target
Cysteinyl leukotriene receptor 1/2
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: 5nM
Assay Description:
In vitro for antagonistic activity against LTD4 receptor in guinea pig ileum
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Target
Cysteinyl leukotriene receptor 1
(Homo sapiens (Human))
University of California Irvine
Curated by
PDSP K
i
Database
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: 14nM
Assay Description:
Antagonist activity against CysLT1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of LTD4-induced calcium mobilization pr...
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Target
Cysteinyl leukotriene receptor 1
(GUINEA PIG)
Ici Pharmaceuticals Group
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Copy SMILES
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Affinity Data
IC50: 44nM
Assay Description:
Compound was evaluated in vitro for inhibition of [3H]-LTD4 binding to guinea pig lung membrane
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Target
Sodium/bile acid cotransporter
(Homo sapiens (Human))
Southwest Jiaotong University
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Inhibition of preS1-peptide binding to human HA-tagged NTCP in U2OS expresseing NTCP in incubated for 24 hrs using Myrcludex B as substrate by compet...
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Target
Cysteinyl leukotriene receptor 2
(Homo sapiens (Human))
University of California Irvine
Curated by
PDSP K
i
Database
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Antagonist activity at human CysLT2 receptor
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Target
Multidrug and toxin extrusion protein 1
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: 1.30E+3nM
Assay Description:
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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Target
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human))
Goethe University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by sp...
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Target
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human))
Goethe University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of sEH (unknown origin)
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Target
Kelch-like ECH-associated protein 1
(Homo sapiens (Human))
TBA
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: 5.87E+3nM
Assay Description:
Inhibition of human Keap1-Nrf2 protein-protein interaction by ELISA method
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Target
Sodium/bile acid cotransporter
(Homo sapiens (Human))
Southwest Jiaotong University
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: 6.50E+3nM
Assay Description:
Inhibition of human NTCP mediated TCA uptake in U2OS expresseing HA-tagged NTCP cells preincubated for 10 mins followed by substrate addition and mea...
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Target
Sodium/bile acid cotransporter
(Homo sapiens (Human))
Southwest Jiaotong University
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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IC50: 6.50E+3nM
Assay Description:
Inhibition of HA-tagged human NTCP expressed in human U2OS cells assessed as reduction in [14C]taurocholate uptake preincubated for 10 mins followed ...
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Cysteinyl leukotriene receptor 2
(Homo sapiens (Human))
University of California Irvine
Curated by
PDSP K
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Database
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: 7.40E+3nM
Assay Description:
Antagonist activity at human CysLT2 expressed in HEK293T cells assessed as inhibition of LTC4-induced effect preincubated for 30 mins prior to LTC4 a...
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Multidrug and toxin extrusion protein 2
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: 7.60E+3nM
Assay Description:
Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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Target
Solute carrier family 22 member 2
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: 9.70E+3nM
Assay Description:
Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibitory concentration against Alpha-1 adrenergic receptor
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Target
Mu-type opioid receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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IC50: >1.00E+4nM
Assay Description:
Inhibitory concentration against Opioid receptor mu 1
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Target
Adenosine receptor A1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibitory concentration against Adenosine A1 receptor
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Histamine H1 receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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IC50: >1.00E+4nM
Assay Description:
Inhibitory concentration against H1 receptor
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D(2) dopamine receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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IC50: >1.00E+4nM
Assay Description:
Inhibitory concentration against Dopamine receptor D2
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Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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IC50: >1.00E+4nM
Assay Description:
Inhibitory concentration against Alpha-2 adrenergic receptor
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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IC50: >1.00E+4nM
Assay Description:
Inhibitory concentration against muscarinic receptor
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Beta-1/Beta-2/Beta-3 adrenergic receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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IC50: >1.00E+4nM
Assay Description:
Inhibitory concentration against Beta adrenergic receptor
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Serotonin 2 (5-HT2) receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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IC50: >1.00E+4nM
Assay Description:
Inhibitory concentration against 5-hydroxytryptamine 2 receptor
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Bile salt export pump
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: 1.11E+4nM
Assay Description:
Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell plasma membrane vesicles assessed as reduction in ATP-dependent [3H]-...
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Target
Bile salt export pump
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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IC50: 1.11E+4nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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IC50: 1.21E+4nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Cysteinyl leukotriene receptor 2
(Homo sapiens (Human))
University of California Irvine
Curated by
PDSP K
i
Database
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
IC50: 5.80E+4nM
Assay Description:
Antagonist activity against CysLT2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of LTD4-induced calcium mobilization pr...
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ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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IC50: 5.88E+4nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Cytosolic phospholipase A2
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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IC50: 8.50E+4nM
Assay Description:
In vitro inhibition of cystolic phospholipase A2 alpha.
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ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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Nuclear receptor subfamily 1 group I member 2
(Homo sapiens (Human))
National Institutes Of Health Chemical Genomics Center
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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EC50: 9.50E+3nM
Assay Description:
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
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Nuclear receptor subfamily 1 group I member 2
(Rattus norvegicus)
National Institutes Of Health Chemical Genomics Center
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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EC50: 5.84E+4nM
Assay Description:
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
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Streptokinase A
(Streptococcus pyogenes M1 GAS)
Broad Institute
Curated by
PubChem BioAssay
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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EC50: 5.00E+4nM
Assay Description:
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...
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Target
Bile acid receptor
(Homo sapiens (Human))
TBA
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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EC50: 3.90E+3nM
Assay Description:
Agonist activity at FXR in human HeLa cells incubated for 24 hrs by Dual-Glo luciferase assay
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Nuclear receptor subfamily 1 group I member 2
(Homo sapiens (Human))
National Institutes Of Health Chemical Genomics Center
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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EC50: 1.41E+4nM
Assay Description:
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
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Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human))
Goethe University Frankfurt
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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EC50: 2.44E+3nM
Assay Description:
Partial agonist activity at human PPARgamma LBD expressed HEK293T cells after 12 to 14 hrs by dual-glo luciferase reporter gene assay
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Nuclear receptor subfamily 1 group I member 2
(Homo sapiens (Human))
National Institutes Of Health Chemical Genomics Center
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
EC50: 3.06E+4nM
Assay Description:
Activation of human PXR expressed in DPX2 cells assessed as CYP3A4 induction after 24 hrs by luciferase reporter gene assay
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Target
Nuclear receptor subfamily 1 group I member 2
(Homo sapiens (Human))
National Institutes Of Health Chemical Genomics Center
Curated by
ChEMBL
Ligand
BDBM50009073
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
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Affinity Data
EC50: 710nM
Assay Description:
Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assay
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