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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human))
Genentech
Curated by
ChEMBL
Ligand
BDBM50398660
(CHEMBL2178142 | US8802674, 61)
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Affinity Data
Ki: 9nM
Assay Description:
Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human))
Genentech
Curated by
ChEMBL
Ligand
BDBM50398660
(CHEMBL2178142 | US8802674, 61)
Copy SMILES
Copy InChI
Affinity Data
Ki: 10.4nM
Assay Description:
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human))
Genentech
Curated by
ChEMBL
Ligand
BDBM50398660
(CHEMBL2178142 | US8802674, 61)
Copy SMILES
Copy InChI
Affinity Data
IC50: 69nM
Assay Description:
Inhibition of autophosphorylation of LRRK2 in human HEK293 cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI