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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 25 hits in this display   

TargetCytochrome P450 1B1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataKi:  3nMAssay Description:Inhibition of human liver microsomes CYP1B1 expressed in baculovirus infected insect cells coexpressing human NADPH-cytochrome P450 reductase using 7...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataKi:  4.40nM ΔG°:  -47.7kJ/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataKi:  55nM ΔG°:  -41.4kJ/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataKi:  213nM ΔG°:  -38.1kJ/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataKi:  220nMAssay Description:Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataKi:  440nM ΔG°:  -36.3kJ/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of human liver microsomes CYP1B1 expressed in Escherichia coli DH5alpha cell membranes coexpressing human NADPH-cytochrome P450 reductase ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.5kJ/moleT: 2°CAssay Description:Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human CYP1B1 by EROD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50:  56nMAssay Description:Inhibition of human CYP1A1 by EROD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol hexakisphosphate kinase 2(Homo sapiens)
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human IP6K2 using insP6 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of human CYP1A2 by EROD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol polyphosphate multikinase(Homo sapiens)
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human IPMK using insP3 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50:  2.51E+3nMAssay Description:Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Konkuk University

LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50:  4.34E+3nMAssay Description:The kinase assay was performed using the EMD Millipore KinaseProfiler service assay protocol. Aurora B kinase was supplied by EMD Millipore Corp. The...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-acyl-carrier protein reductase(Plasmodium falciparum)
University Of Zurich

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of FabIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Eberhard Karls University Of Tuebingen

LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50:  6.30E+3nMT: 2°CAssay Description:The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-acyl-carrier protein reductase(Plasmodium falciparum)
University Of Zurich

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of FabGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard Karls University Of Tuebingen

LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50:  2.01E+4nMT: 2°CAssay Description:The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Sus scrofa (Pig))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50: >7.00E+4nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate assessed as formation of p-nitrophenol preincubated for 15 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Fukuyama University

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50: >9.50E+4nMAssay Description:Inhibition of pig lens aldose reductase by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOligo-1,6-glucosidase IMA1(Saccharomyces cerevisiae S288c (Baker's yeast))
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DataIC50:  1.60E+5nMAssay Description:Inhibition of baker's yeast alpha-glucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-amylase 1A(Homo sapiens (Human))
Nestle Research Center

LigandPNGBDBM23409(3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-...)
Affinity DatapH: 6.0 T: 2°CAssay Description:The assay was carried out at room temperature for 10 min with salivary alpha-amylase, starch, and test compounds. The reducing sugar was determined b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed