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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
23
hits in this display
Target
Melatonin receptor type 1B
(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
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Affinity Data
Ki: 0.140nM
More data for this Ligand-Target Pair
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Target
Melatonin receptor type 1B
(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
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Affinity Data
Ki: 0.200nM
Assay Description:
Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constant
More data for this Ligand-Target Pair
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Target
Melatonin receptor type 1B
(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
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Copy InChI
Affinity Data
Ki: 0.200nM
Assay Description:
Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells
More data for this Ligand-Target Pair
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Target
Melatonin receptor type 1B
(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.230nM
More data for this Ligand-Target Pair
Target Info
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Target
Melatonin receptor type 1A
(Sheep)
Massachusetts General Hospital
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
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Affinity Data
Ki: 0.25nM
More data for this Ligand-Target Pair
Target Info
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Target
Melatonin receptor type 1A/1B/1C
(Gallus gallus)
University Of Groningen
Curated by
ChEMBL
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
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Affinity Data
Ki: 0.340nM
Assay Description:
Binding affinity to compete for 2-[125I]iodomelatonin binding to chicken retinal membranes
More data for this Ligand-Target Pair
Target Info
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Target
Melatonin receptor type 1A
(GUINEA PIG)
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
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Affinity Data
Ki: 0.460nM
More data for this Ligand-Target Pair
Target Info
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Target
Melatonin receptor type 1B
(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.660nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Melatonin receptor type 1A
(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.670nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
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In Depth
Details
PubMed
Copy BDB DOI
Target
Melatonin receptor type 1A
(GUINEA PIG)
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.740nM
More data for this Ligand-Target Pair
Target Info
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
Patents
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In Depth
Details
PubMed
Copy BDB DOI
Target
Melatonin receptor type 1A/1B
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.990nM
Assay Description:
Binding affinity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin (100 pM) as labelled ligand
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Melatonin receptor type 1A/1B
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.990nM
Assay Description:
Binding affinity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligand
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Melatonin receptor type 1A
(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.86nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Melatonin receptor type 1B
(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
Ligand Info
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CHEMBL
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Copy BDB DOI
Target
Melatonin receptor type 1A/1B
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.20nM
Assay Description:
Inhibition of 2-[125I]iodomelatonin binding to melatonin receptor in quail brain as 1/Ka
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Melatonin receptor type 1B
(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.69nM
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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GoogleScholar
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Target
Melatonin receptor
(RABBIT)
Rowett Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4nM
More data for this Ligand-Target Pair
Target Info
UniProtKB/TrEMBL
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Ligand Info
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Copy BDB DOI
Target
Melatonin receptor type 1A
(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.78nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Melatonin receptor type 1A
(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 11nM
Assay Description:
Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constant
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Melatonin receptor type 1A
(Homo sapiens (Human))
Glaxo Wellcome Research And Development
Curated by
PDSP K
i
Database
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 11nM
Assay Description:
Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Melatonin receptor type 1A/1B
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.0400nM
Assay Description:
Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
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antibodypedia
antibodypedia
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Ligand Info
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CHEMBL
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Melatonin receptor type 1A/1B
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.60nM
Assay Description:
Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as radiolabeled ligand
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Melatonin receptor type 1A/1B
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50043289
(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.60nM
Assay Description:
Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligand
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI