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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
19
hits in this display
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Griffith University
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
Ki: 960nM
Assay Description:
Inhibition of human carbonic anhydrase 9 preincubated for 6 hrs by CO2 hydration stopped-flow assay
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Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Griffith University
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
Ki: 4.05E+3nM
Assay Description:
Inhibition of human carbonic anhydrase 12 preincubated for 6 hrs by CO2 hydration stopped-flow assay
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Target
Carbonic anhydrase 7
(Homo sapiens (Human))
Griffith University
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
Ki: 8.71E+3nM
Assay Description:
Inhibition of human carbonic anhydrase 7 preincubated for 6 hrs by CO2 hydration stopped-flow assay
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Griffith University
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
Ki: 1.06E+4nM
Assay Description:
Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs by CO2 hydration stopped-flow assay
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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human))
Dalian University Of Technology
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
Ki: 1.35E+4nM
Assay Description:
Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 13
(Homo sapiens (Human))
Griffith University
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
Ki: 1.78E+4nM
Assay Description:
Inhibition of human carbonic anhydrase 13 preincubated for 6 hrs by CO2 hydration stopped-flow assay
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Griffith University
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
Ki: >1.00E+5nM
Assay Description:
Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs by CO2 hydration stopped-flow assay
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid lipoxygenase ALOX15
(Oryctolagus cuniculus (rabbit))
Tahitian Noni International
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
IC50: 1.65E+4nM
Assay Description:
Inhibition of 15LOX in rabbit reticulocytes by EIA assay
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Target
Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
Sunchon National University
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by spectrophotom...
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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human))
Dalian University Of Technology
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
IC50: 2.26E+4nM
Assay Description:
Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...
More data for this Ligand-Target Pair
Target Info
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Target
Acetylcholinesterase
(Electrophorus electricus (Electric eel))
Sunchon National University
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
IC50: 3.58E+4nM
Assay Description:
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's metho...
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Sunchon National University
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
IC50: >6.00E+4nM
Assay Description:
Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using benzylamine as substrate after 30 mins by spectrophoto...
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Target
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human))
University Of Toyama
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
IC50: 7.44E+4nM
Assay Description:
Inhibition human recombinant aldose reductase 1 by spectrophotometric analysis
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Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Tahitian Noni International
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of human recombinant COX2 expressed in insect Sf21 cells by EIA assay
More data for this Ligand-Target Pair
Target Info
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human))
Tahitian Noni International
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of 5LOX in human PBMC by EIA assay
More data for this Ligand-Target Pair
Target Info
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Target
Sorbitol dehydrogenase
(Homo sapiens (Human))
University Of Toyama
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
IC50: 1.37E+5nM
Assay Description:
Inhibition sorbitol dehydrogenase by spectrophotometric analysis
More data for this Ligand-Target Pair
Target Info
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Target
Acetylcholinesterase
(Homo sapiens (Human))
Leopold-Franzens University Of Innsbruck
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
IC50: 1.69E+5nM
Assay Description:
Inhibition of AChE by microplate assay
More data for this Ligand-Target Pair
Target Info
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Target
Glyceraldehyde-3-phosphate dehydrogenase
(Homo sapiens (Human))
Universidade Federal De Minas Gerais
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
IC50: 2.57E+5nM
Assay Description:
Inhibitory concentration against glyceraldehyde-3-phosphate dehydrogenase was determined as log 1/IC50
More data for this Ligand-Target Pair
Target Info
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Target
Acetylcholinesterase
(Mus musculus (mouse))
Kyung Hee University
Curated by
ChEMBL
Ligand
BDBM50156693
(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
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Affinity Data
IC50: 4.76E+5nM
Assay Description:
Inhibition of ICR mouse brain AChE using acetylthiocholine iodide as substrate incubated 10 mins prior to substrate addition measured after 10 mins b...
More data for this Ligand-Target Pair
Target Info
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