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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 19 hits in this display   

TargetCarbonic anhydrase 9(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataKi:  960nMAssay Description:Inhibition of human carbonic anhydrase 9 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataKi:  4.05E+3nMAssay Description:Inhibition of human carbonic anhydrase 12 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataKi:  8.71E+3nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataKi:  1.06E+4nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataKi:  1.35E+4nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 13(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataKi:  1.78E+4nMAssay Description:Inhibition of human carbonic anhydrase 13 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Tahitian Noni International

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataIC50:  1.65E+4nMAssay Description:Inhibition of 15LOX in rabbit reticulocytes by EIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by spectrophotom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Dalian University Of Technology

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataIC50:  2.26E+4nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataIC50:  3.58E+4nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using benzylamine as substrate after 30 mins by spectrophoto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataIC50:  7.44E+4nMAssay Description:Inhibition human recombinant aldose reductase 1 by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tahitian Noni International

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant COX2 expressed in insect Sf21 cells by EIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Tahitian Noni International

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5LOX in human PBMC by EIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSorbitol dehydrogenase(Homo sapiens (Human))
University Of Toyama

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataIC50:  1.37E+5nMAssay Description:Inhibition sorbitol dehydrogenase by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Leopold-Franzens University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataIC50:  1.69E+5nMAssay Description:Inhibition of AChE by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase(Homo sapiens (Human))
Universidade Federal De Minas Gerais

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataIC50:  2.57E+5nMAssay Description:Inhibitory concentration against glyceraldehyde-3-phosphate dehydrogenase was determined as log 1/IC50More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50156693(6-Methoxy-7-hydroxycoumarin | 6-Methylesculetin | ...)
Affinity DataIC50:  4.76E+5nMAssay Description:Inhibition of ICR mouse brain AChE using acetylthiocholine iodide as substrate incubated 10 mins prior to substrate addition measured after 10 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed