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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
hits in this display
Target
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human))
University Of Manchester
Curated by
ChEMBL
Ligand
BDBM4627
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-fluoro-2...)
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Affinity Data
IC50: 0.75nM
Assay Description:
Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
University Of Manchester
Curated by
ChEMBL
Ligand
BDBM4627
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-fluoro-2...)
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Affinity Data
IC50: 2.30nM
Assay Description:
Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
University Of Manchester
Curated by
ChEMBL
Ligand
BDBM4627
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-fluoro-2...)
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Copy InChI
Affinity Data
IC50: 3nM
T: 2°C
Assay Description:
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
University Of Manchester
Curated by
ChEMBL
Ligand
BDBM4627
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-fluoro-2...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9.5nM
Assay Description:
Inhibition of KDR (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based lumine...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human))
Astrazeneca
Ligand
BDBM4627
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-fluoro-2...)
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Affinity Data
IC50: 30nM
pH: 7.4 T: 2°C
Assay Description:
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human))
University Of Manchester
Curated by
ChEMBL
Ligand
BDBM4627
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-fluoro-2...)
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Copy InChI
Affinity Data
IC50: 41nM
Assay Description:
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ...
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Fibroblast growth factor receptor 1
(Homo sapiens (Human))
Astrazeneca
Ligand
BDBM4627
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-fluoro-2...)
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Affinity Data
IC50: 2.50E+3nM
T: 2°C
Assay Description:
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI