Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  460nMAssay Description:Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of recombinant human VEGFR-2-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of KDR (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based lumine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50340918(4-(4-Bromo-2-fluoroanilino)-6,7-dimethoxyquinazoli...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of human EGFR-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed