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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Gsk
Ligand
BDBM26477
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-2-methylph...)
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Affinity Data
IC50: 0.600nM
pH: 7.5 T: 2°C
Assay Description:
The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human))
University Of Manchester
Curated by
ChEMBL
Ligand
BDBM26477
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-2-methylph...)
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Affinity Data
IC50: 4.60nM
Assay Description:
Inhibition of human RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus system preincubated for 15 mins followed by substrate addi...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Gsk
Ligand
BDBM26477
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-2-methylph...)
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Copy InChI
Affinity Data
IC50: 18nM
Assay Description:
Inhibition of recombinant His-tagged human KDR expressed in insect Sf21 cells preincubated for 15 mins followed by substrate addition measured after ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human))
Gsk
Ligand
BDBM26477
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-2-methylph...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 88nM
Assay Description:
Inhibition of KDR (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based lumine...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Kinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human))
University Of Manchester
Curated by
ChEMBL
Ligand
BDBM26477
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-2-methylph...)
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Copy InChI
Affinity Data
IC50: 500nM
Assay Description:
Inhibition of KIF5B/RET (unknown origin) expressed in mouse BA/F3 cells assessed as reduction in cell viability after 48 hrs by Cell titre glo-based ...
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI