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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 13 hits in this display   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  29nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  30nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation.More data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  50nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
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TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  201nMAssay Description:Inhibition of EGFR (unknown origin) using biotinylated-PTP1B (Tyr66) as substrate incubated for 5 mins prior to substrate addition measured after 1 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  5.10E+3nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Rajiv Gandhi Proudyogiki Vishwavidyalaya

Curated by ChEMBL
LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50: >1.00E+4nMAssay Description:inhibition of human recombinant CDK5/p25 using histone H1 as substrate by scintillation counting in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of p56lck kinase autophosphorylation in Jurkat cellsMore data for this Ligand-Target Pair
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TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(RAT)
Rajiv Gandhi Proudyogiki Vishwavidyalaya

Curated by ChEMBL
LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate by scintillation counting in presence ...More data for this Ligand-Target Pair
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TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM3530(6,7-dimethoxy-N-phenylquinazolin-4-amine | CHEMBL5...)
Affinity DataIC50: >5.00E+4nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In DepthDetails Article