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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Sapienza University Of Rome
Ligand
BDBM29142
(substituted chalcone, 5i)
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Affinity Data
IC50: 4.40nM
pH: 7.4 T: 2°C
Assay Description:
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Sapienza University Of Rome
Ligand
BDBM29142
(substituted chalcone, 5i)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.37E+3nM
Assay Description:
Inhibition of MAO-B (unknown origin)
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Target Info
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UniProtKB/SwissProt
antibodypedia
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Ligand Info
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Target
Broad substrate specificity ATP-binding cassette transporter ABCG2
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM29142
(substituted chalcone, 5i)
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Affinity Data
IC50: 1.07E+4nM
Assay Description:
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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In Depth
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Article
PubMed
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Target
Broad substrate specificity ATP-binding cassette transporter ABCG2
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM29142
(substituted chalcone, 5i)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.35E+4nM
Assay Description:
Inhibition of BCRP in human MCF7/MX cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by Fluorometry
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
Sapienza University Of Rome
Ligand
BDBM29142
(substituted chalcone, 5i)
Copy SMILES
Copy InChI
Affinity Data
Assay Description:
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI