Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Theravance

US Patent
LigandPNGBDBM103813(US8551978, I-83 | US8816088, I-83 | US9394275, I-8...)
Affinity DataKi:  0.200nMAssay Description:Radioligand binding assay using muscarinic receptors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Theravance

US Patent
LigandPNGBDBM103813(US8551978, I-83 | US8816088, I-83 | US9394275, I-8...)
Affinity DataKi:  0.200nMAssay Description:Radioligand binding assays for cloned muscarinic receptors were performed in 96-well microtiter plates in a total assay volume of 100 uL. CHO cell me...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Theravance

US Patent
LigandPNGBDBM103813(US8551978, I-83 | US8816088, I-83 | US9394275, I-8...)
Affinity DataKi:  0.200nM ΔG°:  -57.6kJ/moleT: 2°CAssay Description:Displacement assays for determination of Ki values of test compounds were performed with [3H]-NMS at 1 nM and eleven different test compound concentr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Theravance

US Patent
LigandPNGBDBM103813(US8551978, I-83 | US8816088, I-83 | US9394275, I-8...)
Affinity DataKi:  0.200nMAssay Description:compounds were performed with [3H]NMS at 1 nM and eleven different test compound concentrations. The test compounds were initially dissolved to a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Theravance

US Patent
LigandPNGBDBM103813(US8551978, I-83 | US8816088, I-83 | US9394275, I-8...)
Affinity DataKi:  0.200nMAssay Description:Radioligand binding assays for cloned muscarinic receptors were performed in 96-well microtiter plates in a total assay volume of 100 μL. CHO ce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Theravance Respiratory

US Patent
LigandPNGBDBM103813(US8551978, I-83 | US8816088, I-83 | US9394275, I-8...)
Affinity DataEC50:  2nMT: 2°CAssay Description:cAMP assays were performed in a radioimmunoassay format using the Flashplate Adenylyl Cyclase Activation Assay System with [125I]-cAMP (NEN SMP004, P...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Theravance Respiratory

US Patent
LigandPNGBDBM103813(US8551978, I-83 | US8816088, I-83 | US9394275, I-8...)
Affinity DataEC50:  2nMT: 2°CAssay Description:cAMP assays were performed in a radioimmunoassay format using the Flashplate Adenylyl Cyclase Activation Assay System with [125I]-cAMP (NEN SMP004, P...More data for this Ligand-Target Pair
In DepthDetails US Patent