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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
hits in this display
Target
Lysosomal acid glucosylceramidase
(Homo sapiens (Human))
Nankai University
Ligand
BDBM108220
(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
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Affinity Data
Ki: 1.17nM
pH: 5.2
Assay Description:
To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Lysosomal acid glucosylceramidase
(Homo sapiens (Human))
Nankai University
Ligand
BDBM108220
(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
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Affinity Data
IC50: 2.97nM
pH: 5.2
Assay Description:
The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lysosomal acid glucosylceramidase
(Homo sapiens (Human))
Nankai University
Ligand
BDBM108220
(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
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Copy InChI
Affinity Data
IC50: 3.62nM
pH: 7.0
Assay Description:
The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prunasin hydrolase
(Prunus dulcis (Almond))
Nankai University
Ligand
BDBM108220
(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
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Affinity Data
IC50: 78nM
pH: 10.6 T: 2°C
Assay Description:
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....
More data for this Ligand-Target Pair
Target Info
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Beta-galactosidase
(Bos taurus (Bovine))
Nankai University
Ligand
BDBM108220
(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
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Affinity Data
IC50: 92nM
pH: 10.6 T: 2°C
Assay Description:
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....
More data for this Ligand-Target Pair
Target Info
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Oligo-1,6-glucosidase IMA1
(Saccharomyces cerevisiae S288c (Baker's yeast))
Nankai University
Ligand
BDBM108220
(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
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Affinity Data
IC50: 300nM
pH: 10.6 T: 2°C
Assay Description:
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Alpha-galactosidase
(Coffea arabica (Coffee beans))
Nankai University
Ligand
BDBM108220
(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
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Affinity Data
IC50: 4.90E+3nM
pH: 10.6 T: 2°C
Assay Description:
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....
More data for this Ligand-Target Pair
Target Info
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI