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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
43
hits in this display
Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
University Of North Carolina At Chapel Hill
Curated by
PDSP K
i
Database
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
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Affinity Data
Ki: 0.570nM
More data for this Ligand-Target Pair
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.710nM
Assay Description:
Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
University Of North Carolina At Chapel Hill
Curated by
PDSP K
i
Database
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.740nM
More data for this Ligand-Target Pair
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.950nM
Assay Description:
Binding affinity to human histamine H1 receptor by radioligand displacement assay
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.01nM
More data for this Ligand-Target Pair
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.18nM
More data for this Ligand-Target Pair
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
University Of North Carolina At Chapel Hill
Curated by
PDSP K
i
Database
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.25nM
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.30nM
Assay Description:
Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by m...
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.60nM
Assay Description:
Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.70nM
Assay Description:
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cells
More data for this Ligand-Target Pair
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.70nM
Assay Description:
Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.09nM
Assay Description:
Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting
More data for this Ligand-Target Pair
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.5nM
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.70nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.98nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4nM
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.47nM
Assay Description:
Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting
More data for this Ligand-Target Pair
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Target
Histamine H1 receptor
(RAT)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.5nM
More data for this Ligand-Target Pair
Target Info
Reactome pathway
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PubMed
Copy BDB DOI
Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.70nM
More data for this Ligand-Target Pair
Target Info
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KEGG
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Ligand Info
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Target
Hrh3 protein
(RAT)
Glaxo Research & Development
Curated by
PDSP K
i
Database
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 7.94E+3nM
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Target
Histamine H3 receptor
(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Janssen Research Foundation
Curated by
PDSP K
i
Database
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
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Target
Hrh3 protein
(RAT)
Glaxo Research & Development
Curated by
PDSP K
i
Database
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM ΔG°: >-29.7kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...
More data for this Ligand-Target Pair
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Target
Hrh3 protein
(RAT)
Glaxo Research & Development
Curated by
PDSP K
i
Database
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.0140nM
Assay Description:
Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cells
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.820nM
Assay Description:
Binding affinity to human histamine H1 receptor by radioligand displacement assay
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
Universit£
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.30nM
Assay Description:
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.40nM
Assay Description:
Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
More data for this Ligand-Target Pair
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
University Of North Carolina At Chapel Hill
Curated by
PDSP K
i
Database
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.5nM
Assay Description:
Inhibition of guinea pig histamine H1 receptor
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.5nM
Assay Description:
Binding affinity to human histamine H1 receptor by radioligand displacement assay
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.90nM
Assay Description:
Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3nM
Assay Description:
Antagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ release
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
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IC50: 3.30nM
Assay Description:
Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrs
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Target
Histamine H1 receptor
(RAT)
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
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IC50: 5.75nM
Assay Description:
Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation counting
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
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IC50: 10nM
Assay Description:
Inverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assay
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
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Affinity Data
IC50: 13nM
Assay Description:
Inhibitory activity against human Histamine H1 receptor
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
University Of North Carolina At Chapel Hill
Curated by
PDSP K
i
Database
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
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IC50: 34nM
Assay Description:
In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
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Affinity Data
IC50: 46.8nM
Assay Description:
Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
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IC50: 1.10E+3nM
Assay Description:
Inhibitory concentration against IKr potassium channel
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
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IC50: >1.00E+6nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Target
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig))
University Of North Carolina At Chapel Hill
Curated by
PDSP K
i
Database
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
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Affinity Data
Kd: 0.851nM
Assay Description:
Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins
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Target
Histamine H1 receptor
(Homo sapiens (Human))
The University Of Newcastle
Curated by
ChEMBL
Ligand
BDBM22567
(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
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Affinity Data
EC50: 2.60nM
Assay Description:
Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cells
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