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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50278942
(CHEMBL499905 | D-2-(4-(but-2-ynyloxy)phenylsulfona...)
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Affinity Data
IC50: 80nM
Assay Description:
Inhibition of TACE by FRET assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50278942
(CHEMBL499905 | D-2-(4-(but-2-ynyloxy)phenylsulfona...)
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Affinity Data
IC50: 1.44E+3nM
Assay Description:
Inhibition of MMP2 by FLIPR assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Collagenase 3
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50278942
(CHEMBL499905 | D-2-(4-(but-2-ynyloxy)phenylsulfona...)
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Affinity Data
IC50: 4.56E+3nM
Assay Description:
Inhibition of MMP13 by FLIPR assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50278942
(CHEMBL499905 | D-2-(4-(but-2-ynyloxy)phenylsulfona...)
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Affinity Data
IC50: 1.30E+4nM
Assay Description:
Inhibition of MMP14 by FLIPR assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Interstitial collagenase
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50278942
(CHEMBL499905 | D-2-(4-(but-2-ynyloxy)phenylsulfona...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of MMP1 by FLIPR assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Disintegrin and metalloproteinase domain-containing protein 17
(Mus musculus (Mouse))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50278942
(CHEMBL499905 | D-2-(4-(but-2-ynyloxy)phenylsulfona...)
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Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of TACE in mouse Raw264.7 cells assessed as inhibition of LPS-induced TNFalpha production treated 1 hr before LPS challenge measured 4 hrs...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI