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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185585(US9156852, 16 | USRE47451, Example 16)
Affinity DataIC50:  5nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185585(US9156852, 16 | USRE47451, Example 16)
Affinity DataIC50:  5nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [409-765](Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185585(US9156852, 16 | USRE47451, Example 16)
Affinity DataIC50:  15nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185585(US9156852, 16 | USRE47451, Example 16)
Affinity DataIC50:  15nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185585(US9156852, 16 | USRE47451, Example 16)
Affinity DataIC50:  32nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM185585(US9156852, 16 | USRE47451, Example 16)
Affinity DataIC50:  32nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In DepthDetails US Patent