SMILES String Search

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 97 hits in this display

Voltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

IC50: <1.58E+4nMAssay Description:Antagonist activity at human CaV1.2 channel expressed in HEK293 cells by FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <1.58E+4nMAssay Description:Antagonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium level by fluorescence/summary (Abse5) as...More data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <1.58E+4nMAssay Description:Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as intracellular calcium level by fluorescence/summary (Abse5) as...More data for this Ligand-Target Pair

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Melanocortin receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <2.51E+4nMAssay Description:Antagonist activity at human MC4 receptor assessed as cAMP level by HTRF LANCE/summary (Abse5) assayMore data for this Ligand-Target Pair

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Peroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <2.51E+4nMAssay Description:Binding affinity to human PPARgamma by SPA/summary (Abse5) assayMore data for this Ligand-Target Pair

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Peroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <2.51E+4nMAssay Description:Binding affinity to human PPARgamma by SPA/Abse5 assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Peroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <2.51E+4nMAssay Description:Binding affinity to human PPARdelta by SPA/summary (Abse5) assayMore data for this Ligand-Target Pair

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Peroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <2.51E+4nMAssay Description:Binding affinity to human PPARdelta by SPA/Abse5 assayMore data for this Ligand-Target Pair

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Activin receptor type-2B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <2.51E+4nMAssay Description:Antagonist activity at human ACVR2B by Ant A204 luciferase reporter/summary (Abse5) assayMore data for this Ligand-Target Pair

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Glycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <2.51E+4nMAssay Description:Inhibition of human GSK3B by FP assayMore data for this Ligand-Target Pair

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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <2.51E+4nMAssay Description:Inhibition of human PDE4B by luminescence assayMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <2.51E+4nMAssay Description:Inhibition of human PI3K gamma by TR-FRET/summary (Abse5) assayMore data for this Ligand-Target Pair

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Peroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <2.51E+4nMAssay Description:Binding affinity to human PPARalpha by SPA/Abse5 assayMore data for this Ligand-Target Pair

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Peroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <2.51E+4nMAssay Description:Binding affinity to human PPARalpha by SPA/summary (Abse5) assayMore data for this Ligand-Target Pair

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D(2) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.02E+4nMAssay Description:Antagonist activity at human dopamine D2 receptor by GTPgS SPA assayMore data for this Ligand-Target Pair

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D(2) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.16E+4nMAssay Description:Antagonist activity at human dopamine D2 receptor by GTPgS SPA/summary (Abse5) assayMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.16E+4nMAssay Description:Antagonist activity at human beta 2 adrenergic receptor by TR FRET/summary (Abse5) assayMore data for this Ligand-Target Pair

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Free fatty acid receptor 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.16E+4nMAssay Description:Antagonist activity at human GPR41 expressed in U2OS cells by brilliant black FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.16E+4nMAssay Description:Antagonist activity at human 5-HT1B receptor by LEADseeker GTPgS/summary (Abse5) assayMore data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily M member 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.98E+4nMAssay Description:Blocking of human TRPM5 expressed in HEK293 cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.98E+4nMAssay Description:Antagonist activity at human 5-HT2A receptor expressed in HEK cells by luminescence/summary (Abse5) assayMore data for this Ligand-Target Pair

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Solute carrier family 15 member 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.98E+4nMAssay Description:Antagonist activity at human PePT1 receptor expressed in HEK cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair

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Sodium/glucose cotransporter 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.98E+4nMAssay Description:Inhibition of human SGLT1 expressed in U2OS cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair

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Solute carrier family 5 (neutral amino acid transporters, system A), member 4b(Mus musculus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.98E+4nMAssay Description:Inhibition of mouse SGLT3b expressed in U2OS cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair

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Taste receptor type 2 member 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.98E+4nMAssay Description:Antagonist activity at human TAS2R14 expressed in U2OS cells by Ga16gust44 Clone 7A FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Histamine H1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.98E+4nMAssay Description:Antagonist activity at human histamine H1 receptor by luminescence assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Short transient receptor potential channel 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.98E+4nMAssay Description:Blocking of human TRPC3 expressed in HEK cells by MSRII FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Taste receptor type 2 member 16(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.98E+4nMAssay Description:Antagonist activity at human TAS2R16 expressed in U2OS cells by Ga16gust44 Clone 7A FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

Reactome pathway
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Free fatty acid receptor 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.98E+4nMAssay Description:Antagonist activity at human GPR43 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Alpha-1B adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.98E+4nMAssay Description:Antagonist activity at human adrenergic alpha1B receptor assessed as intracellular calcium by summary (Abse5) assayMore data for this Ligand-Target Pair

Reactome pathway
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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <3.98E+4nMAssay Description:Antagonist activity at human 5-HT2C receptor expressed in CHO cells by luminescence/summary (Abse5) assayMore data for this Ligand-Target Pair

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Potassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <5.01E+4nMAssay Description:Inhibition of human Kv1.5 expressed in CHO cells by electrophysiologyMore data for this Ligand-Target Pair

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Substance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <5.01E+4nMAssay Description:Antagonist activity at human NK1 receptor by FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Vasopressin V1a receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <5.01E+4nMAssay Description:Antagonist activity at human vasopressin V1a receptor by double wash FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <5.01E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by summary (Abse5) assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <5.01E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by dofetilide binding assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Glucagon receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <5.01E+4nMAssay Description:Antagonist activity at human glucagon receptor expressed in CHO-K1 cells by LANCE HTRF/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB MMDB
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Gastric inhibitory polypeptide receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <5.01E+4nMAssay Description:Antagonist activity at human GIP receptor expressed in HEK293 cells by IP4 HTRF EFC cAMP/summary (Abse5) assayMore data for this Ligand-Target Pair

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Mu-type opioid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <1.00E+5nMAssay Description:Antagonist activity at human OPRM1 receptor by BacMam GTPgS LEADseeker/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Kappa-type opioid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <1.00E+5nMAssay Description:Antagonist activity at human OPRK1 receptor by BacMam GTPgS LEADseeker/summary (Abse5) assayMore data for this Ligand-Target Pair

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Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <1.00E+5nMAssay Description:Inhibition of human NET by BacMam bind SPA/summary (Abse5) assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <1.00E+5nMAssay Description:Inhibition of human Nav1.5 expressed in HEK cells by electrophysiologyMore data for this Ligand-Target Pair

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Sodium-dependent dopamine transporter(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <1.00E+5nMAssay Description:Inhibition of human DAT by BacMam Binding SPA/summary (Abse5) assayMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Sodium-dependent serotonin transporter(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <1.00E+5nMAssay Description:Inhibition of human SERT by BacMam binding SPA/summary (Abse5) assayMore data for this Ligand-Target Pair

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Prostaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

IC50: <1.00E+5nMAssay Description:Inhibition of human COX2 by FLINT/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Free fatty acid receptor 4(Mus musculus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: 6.31E+3nMAssay Description:Agonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISAMore data for this Ligand-Target Pair

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Free fatty acid receptor 4(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: 794nMAssay Description:Agonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair

PDB Reactome pathway
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Free fatty acid receptor 4(Mus musculus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: 631nMAssay Description:Agonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair

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Free fatty acid receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: 501nMAssay Description:Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair

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Transient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <1.26E+5nMAssay Description:Agonist activity at human TRPV4 expressed in HEK cells by aequorin Luminescence/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity at human 5-HT1B receptor by LEADseeker GTPgS/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Adenosine receptor A2a(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity at human adenosine A2A receptor by whole cell LANCE TR-FRET/summary (Abse5) assayMore data for this Ligand-Target Pair

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Alpha-2C adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Activity at human alpha2C adrenergic receptor expressed in CHO-K1 cells assessed as intracellular calcium by LANCE TR FRET/summary (Abse5) assayMore data for this Ligand-Target Pair

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Beta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity at human beta 2 adrenergic receptor by TR FRET/summary (Abse5) assayMore data for this Ligand-Target Pair

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Free fatty acid receptor 1(Mus musculus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity against mouse GPR40 expressed in U2OS cells by FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Free fatty acid receptor 3(Mus musculus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity against mouse GPR41 expressed in U2OS cells by brilliant black FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Melanocortin receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity at human MC4 receptor assessed as cAMP level by HTRF LANCE/summary (Abse5) assayMore data for this Ligand-Target Pair

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Chemerin-like receptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <2.51E+4nMAssay Description:Agonist activity at human CMKLR1 assessed as melanophore absorbance by summary (Abse5) assayMore data for this Ligand-Target Pair

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G-protein coupled receptor 135(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <2.51E+4nMAssay Description:Agonist activity against human GPR135 assessed as melanophore absorbance by summary (Abse5) assayMore data for this Ligand-Target Pair

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Presenilin-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <2.51E+4nMAssay Description:Agonist activity at human PS1 receptor by luciferase reporter/Abse5 assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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Taste receptor type 2 member 9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <2.51E+4nMAssay Description:Agonist activity at human TAS2R9 expressed in U2OS cells by Ga16gust44 Clone 7A FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <1.58E+4nMAssay Description:Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as intracellular calcium level by fluorescence/summary (Abse5) assayMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <1.58E+4nMAssay Description:Agonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as intracellular calcium level by fluorescence/summary (Abse5) assayMore data for this Ligand-Target Pair

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Taste receptor type 2 member 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <1.00E+4nMAssay Description:Agonist activity at human TAS2R14 expressed in U2OS cells by Ga16gust44 Clone 7A FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Taste receptor type 2 member 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <1.00E+4nMAssay Description:Agonist activity at human TAS2R4 expressed in U2OS cells by Ga16gust44 Clone 2B FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Free fatty acid receptor 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity at human FFA3 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Free fatty acid receptor 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity at human FFA2 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair

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Free fatty acid receptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity at human FFA1 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair

PDB Reactome pathway
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Free fatty acid receptor 1(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity at rat FFA1 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Free fatty acid receptor 2(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity at rat FFA2 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair

PDB Reactome pathway
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Free fatty acid receptor 1(Mus musculus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity at mouse FFA1 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Free fatty acid receptor 2(Mus musculus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity at mouse FFA2 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair

PDB Reactome pathway
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Free fatty acid receptor 3(Mus musculus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.16E+4nMAssay Description:Agonist activity at mouse FFA3 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRMore data for this Ligand-Target Pair

Reactome pathway
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Kappa-type opioid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <1.00E+5nMAssay Description:Agonist activity at human OPRK1 receptor by BacMam GTPgS LEADseeker/summary (Abse5) assayMore data for this Ligand-Target Pair

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Mu-type opioid receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <1.00E+5nMAssay Description:Agonist activity at human OPRM1 receptor by BacMam GTPgS LEADseeker/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity at human 5-HT3 receptor by FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity at human 5-HT3 receptor by FLIPR(Abse5) assayMore data for this Ligand-Target Pair

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Endothelin receptor type B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity at human endothelin B receptor expressed in CHO cells by luminescence HTS/summary (Abse5) assayMore data for this Ligand-Target Pair

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Glucagon receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity at human glucagon receptor expressed in CHO cells by luciferase HTS/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB MMDB
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G-protein coupled receptor 39(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity against human GPR39 expressed in CHO cells by BacMam IP1 HTRF/summary (Abse5) assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
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Free fatty acid receptor 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity against human GPR40 expressed in U2OS cells by FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Free fatty acid receptor 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity against human GPR41 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Free fatty acid receptor 3(Mus musculus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity against mouse GPR41 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

Reactome pathway
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G-protein coupled estrogen receptor 1(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity against rat GPR41 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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Free fatty acid receptor 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity against human GPR43 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Free fatty acid receptor 2(Mus musculus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity against mouse GPR43 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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Free fatty acid receptor 2(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity against rat GPR43 expressed in U2OS cells by BacMam FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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Solute carrier family 15 member 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity at human PePT1 receptor expressed in HEK cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Relaxin-3 receptor 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity at human GPR100 expressed in U2OS cells by FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Taste receptor type 2 member 16(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity at human TAS2R16 expressed in U2OS cells by summary (Abse5) assayMore data for this Ligand-Target Pair

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Taste receptor type 2 member 41(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity at human TAS2R41 expressed in U2OS cells by Ga16gust44 Clone 7A FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Taste receptor type 2 member 60(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Agonist activity at human TAS2R60 expressed in U2OS cells by Ga16gust44 Clone 7A FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

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Short transient receptor potential channel 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Induction of human TRPC3 opening expressed in HEK cells by MSRII FLIPR/summary (Abse5) assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Transient receptor potential cation channel subfamily M member 5(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <5.01E+4nMAssay Description:Induction of human TRPM5 opening expressed in HEK293 cells by FLIPR membrane potential/summary (Abse5) assayMore data for this Ligand-Target Pair

Reactome pathway
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5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.98E+4nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in HEK cells by luminescence/summary (Abse5) assayMore data for this Ligand-Target Pair

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5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: <3.98E+4nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in CHO cells by luminescence/summary (Abse5) assayMore data for this Ligand-Target Pair

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Free fatty acid receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50044849(CHEMBL3311308)

EC50: 490nMAssay Description:Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interacti...More data for this Ligand-Target Pair

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Displayed 1 to 50 (of 97 total ) | Next | Last >>

Filter my 97 hits

Targets 57▿
- Free fatty acid receptor 2 7
- Free fatty acid receptor 3 6
- Free fatty acid receptor 1 5
- Free fatty acid receptor 4 5
- Peroxisome proliferator-activated receptor gamma 2
- Glucagon receptor 2
- Transient receptor potential cation channel subfamily M member 5 2
- Solute carrier family 15 member 1 2
- Peroxisome proliferator-activated receptor delta 2
- Short transient receptor potential channel 3 2
- Peroxisome proliferator-activated receptor alpha 2
- Muscarinic acetylcholine receptor M2 2
- Muscarinic acetylcholine receptor M1 2
- Potassium voltage-gated channel subfamily H member 2 2
- Beta-2 adrenergic receptor 2
- Melanocortin receptor 4 2
- Kappa-type opioid receptor 2
- Taste receptor type 2 member 14 2
- 5-hydroxytryptamine receptor 2C 2
- 5-hydroxytryptamine receptor 1B 2
- D(2) dopamine receptor 2
- Taste receptor type 2 member 16 2
- 5-hydroxytryptamine receptor 2A 2
- 5-hydroxytryptamine receptor 3A 2
- Mu-type opioid receptor 2
- Sodium-dependent serotonin transporter 1
- Vasopressin V1a receptor 1
- Presenilin-1 1
- Potassium voltage-gated channel subfamily A member 5 1
- Chemerin-like receptor 1 1
- Sodium-dependent noradrenaline transporter 1
- Sodium/glucose cotransporter 1 1
- Sodium channel protein type 5 subunit alpha 1
- Gastric inhibitory polypeptide receptor 1
- Taste receptor type 2 member 9 1
- Histamine H1 receptor 1
- Taste receptor type 2 member 4 1
- Voltage-dependent L-type calcium channel subunit alpha-1C 1
- Glycogen synthase kinase-3 beta 1
- Transient receptor potential cation channel subfamily V member 4 1
- Prostaglandin G/H synthase 2 1
- Taste receptor type 2 member 41 1
- Substance-P receptor 1
- G-protein coupled receptor 135 1
- G-protein coupled estrogen receptor 1 1
- Relaxin-3 receptor 2 1
- Sodium-dependent dopamine transporter 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 1
- Taste receptor type 2 member 60 1
- Alpha-2C adrenergic receptor 1
- Alpha-1B adrenergic receptor 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- G-protein coupled receptor 39 1
- Activin receptor type-2B 1
- Endothelin receptor type B 1
- Solute carrier family 5 (neutral amino acid transporters, system A), member 4b 1
- Adenosine receptor A2a 1
Publications 2▿
- Bioorg Med Chem Lett 24: 3100-3 (2014) 96
- J Med Chem 59: 8868-8878 (2016) 1
Institutions 2▿
- Glaxosmithkline 96
- University Of Southern Denmark 1
Affinity: 4.9E+2 to 1.3E+5 nM▿
- IC50 45
- EC50 52
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1