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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
15
hits in this display
Target
Macrophage metalloelastase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 32nM
Assay Description:
Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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Article
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Target
Collagenase 3
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 84nM
Assay Description:
Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP13 after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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Article
PubMed
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 98nM
Assay Description:
Inhibition of para-aminophenylmercuric acetate-activated human recombinant pro-MMP9 catalytic domain after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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Article
PubMed
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 98nM
Assay Description:
Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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CHEMBL
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Article
PubMed
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Target
Matrix metalloproteinase-16
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 130nM
Assay Description:
Inhibition of human recombinant pro-MMP16 catalytic domain after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Matrix metalloproteinase-14
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 200nM
Assay Description:
Inhibition of human recombinant pro-MMP14 catalytic domain after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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In Depth
Details
Article
PubMed
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 230nM
Assay Description:
Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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Ligand Info
CHEMBL
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In Depth
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Article
PubMed
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
Copy SMILES
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Affinity Data
IC50: 230nM
Assay Description:
Inhibition of para-aminophenylmercuric acetate-activated human recombinant pro-MMP2 catalytic domain after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
Details
Article
PubMed
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Target
Neutrophil collagenase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 280nM
Assay Description:
Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP8 after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
Details
Article
PubMed
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Target
Stromelysin-1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 730nM
Assay Description:
Inhibition of trypsin activated human pro-MMP3 after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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PC sid
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Article
PubMed
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Target
Interstitial collagenase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 4.10E+3nM
Assay Description:
Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP1 after 4 hrs by fluorimetry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Elastase
(Pseudomonas aeruginosa)
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 1.70E+4nM
Assay Description:
Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobe...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Elastase
(Pseudomonas aeruginosa)
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 2.90E+4nM
Assay Description:
Inhibition of Pseudomonas aeruginosa pseudolysin pretreated with compound for 1 hr followed by the addition of 1.73 uM bradykinin like substrate by s...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
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Article
PubMed
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Target
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human))
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 6.70E+4nM
Assay Description:
Inhibition of recombinant human ADAM17 after 30 mins using FS-6 as substrate by fluorometry
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Thermolysin
(Bacillus thermoproteolyticus)
Uit The Arctic University Of Norway
Curated by
ChEMBL
Ligand
BDBM50299053
(CHEMBL573714 | N-Hydroxy-2-(2-(4-methoxyphenylsulf...)
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Affinity Data
IC50: 1.46E+5nM
Assay Description:
Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrat...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI