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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
132
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Target
Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
University Of Cambridge
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 5nM
Assay Description:
Inhibition of human MAOA
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Target
Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
University Of Cambridge
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 17nM
Assay Description:
Inhibition of human recombinant MAO-A expressed in baculovirus-infected Bacillus thuringiensis israelensis cells after 1 hr by two-step bioluminescen...
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Target
Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
University Of Cambridge
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 17nM
Assay Description:
Inhibition of MAO-A
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Target
Nischarin
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 22nM
Assay Description:
Binding affinity towards Imidazoline I2 receptor
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 33nM
Assay Description:
Competitive inhibition of GST-tagged DYRK1A (unknown origin) expressed in Escherichia coli BL21(DE3) by Lineweaver-Burk plot analysis in presence of ...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 166nM
Assay Description:
Competitive inhibition of GST-tagged DYRK1B (unknown origin) expressed in Escherichia coli BL21(DE3) by Lineweaver-Burk plot analysis in presence of ...
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Target
Alpha-2C adrenergic receptor
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 810nM
Assay Description:
Binding affinity towards Alpha-2C adrenergic receptor
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Target
Alpha-2B adrenergic receptor
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 1.13E+3nM
Assay Description:
Binding affinity towards Imidazoline I2 receptor
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 1.48E+3nM
Assay Description:
Binding affinity towards human 5-hydroxytryptamine 6 receptor
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Target
Alpha-2A adrenergic receptor
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 2.54E+3nM
Assay Description:
Binding affinity towards alpha2A-Adrenergic receptor
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Target
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 3.26E+3nM
Assay Description:
Binding affinity towards NET
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Target
Chitinase
(Onchocerca volvulus)
The Scripps Research Institute
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 3.78E+3nM
Assay Description:
Competitive inhibition of L3 larval stage of Onchocerca volvulus chitinase using 4-methylumbelliferyl-N-N'-N''-beta-chitotrioside as substrate assess...
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5-hydroxytryptamine receptor 7
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 5.50E+3nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 7 receptor
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5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 7.79E+3nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 2A receptor
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5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 9.34E+3nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 2C receptor
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Target
Beta-1 adrenergic receptor
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards Beta-1A adrenergic receptor
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Target
Sodium-dependent dopamine transporter
(BOVINE)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards DAT (bovine)
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Target
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 1D receptor
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 1A receptor
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Target
5-hydroxytryptamine receptor 5A
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards 5-HT5A receptor
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5-hydroxytryptamine receptor 1B
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 1B receptor
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards Alpha-1A adrenergic receptor
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards Serotonin transporter
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Target
Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards Alpha-1B adrenergic receptor
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Target
5-hydroxytryptamine receptor 5A
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards human 5-hydroxytryptamine 5A receptor using LSD as radioligand
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards Beta-2A adrenergic receptor
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Metabotropic glutamate receptor 1/2/3/4/5/6/7/8
(Rattus norvegicus)
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity for rat 5-hydroxytryptamine 2A receptor using [3H]-DOB
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards cloned rat 5-hydroxytryptamine 2A receptor by [3H]-ketanserin displacement.
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Target
D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity towards cloned rat 5-hydroxytryptamine 2A receptor by [3H]-ketanserin displacement.
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Nischarin
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 1.38E+4nM
Assay Description:
Binding affinity towards Imidazoline I1 receptor
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Institut F£R Toxikologie
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 5.00E+4nM
Assay Description:
Inhibitory effect on Bufuralol 1'-hydroxylation by human liver microsomes (Ki = apparent inhibition constant)
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Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
Facult£S Universitaires Notre-Dame De La Paix
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
Ki: 1.21E+5nM
Assay Description:
Inhibition of human recombinant MAO-B expressed in baculovirus-infected Bacillus thuringiensis israelensis cells after 1 hr by two-step bioluminescen...
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Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
University Of Cambridge
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 4.10nM
Assay Description:
Inhibition of recombinant human MAO-A using using kynuramine as substrate assessed as inhibition of 4-hydroxyquinoline formation incubated for 20 min...
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Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
University Of Cambridge
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 4.10nM
Assay Description:
Inhibition of human recombinant MAO-A assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by f...
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Amine oxidase [flavin-containing] A
(Homo sapiens (Human))
University Of Cambridge
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibition of MAOA (unknown origin)
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 8.80nM
Assay Description:
Inhibition of GST-tagged human recombinant DYRK1A by FRET-based LanthaScreen Eu kinase binding assay
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 12nM
Assay Description:
Inhibition of N-terminal GST-fused full-length human DYRK1A (1 to 763 residues) expressed in baculovirus expression system using myelin basic protein...
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 22nM
Assay Description:
Inhibition of human DYRK1A using [33P]-ATP incubated for 120 mins
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Dual specificity protein kinase CLK1
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 26nM
Assay Description:
Inhibition of GST-tagged human recombinant CLK1 expressed in Escherichia coli using RS peptide as substrate incubated for 30 mins in presence of [gam...
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Dual specificity protein kinase CLK1
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 26nM
Assay Description:
Inhibition of human recombinant CLK1-GST expressed in Escherichia coli using GRSRSRSRSRSR as substrate
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 27nM
Assay Description:
Inhibition of DYRK1A (unknown origin) by FRET-based Lantha-screen Eu kinase binding assay
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 28nM
Assay Description:
Inhibition of human recombinant GST-tagged DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by sc...
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT)
Universit£
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 29nM
Assay Description:
Inhibition of rat recombinant DYRK1A-GST expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 29nM
Assay Description:
Inhibition of DYRK1A (unknown origin)
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 29nM
Assay Description:
Inhibition of GST-tagged human recombinant DYRK1A expressed in Escherichia coli using RS peptide as substrate incubated for 30 mins in presence of [g...
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 30nM
Assay Description:
Inhibition of recombinant human DYRK1A (1 to 499 residues) expressed in Escherichia coli using woodtide as substrate incubated for 30 mins in presenc...
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 30nM
Assay Description:
Inhibition of DYRK1A
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 32nM
Assay Description:
Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 33nM
Assay Description:
Inhibition of DYRK1A (unknown origin) using woodtide as substrate after 10 mins in presence of [gamma-33P]ATP by microbeta scintillation counting
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 33nM
Assay Description:
Competitive inhibition of DYRK1A (unknown origin) using ATP
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 33nM
Assay Description:
Inhibition of GST-tagged Dyrk1A (unknown origin) expressed in Escherichia coli using [33P]ATP[gammaP]/DYRKtide as substrate after 5 mins by liquid sc...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT)
Universit£
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 34nM
Assay Description:
Inhibition of rat DYRK1A isolated from brain using KKISGRLSPIMTEQ as substrate and [gamma33P]ATP after 30 mins by scintillation counting
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 41nM
Assay Description:
Inhibition of full-length recombinant human GST-tagged Dyrk1a expressed in baculovirus expression system using Alexa-Fluor tracer-236 incubated for 6...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 48nM
Assay Description:
Inhibition of DYRK1A in human HeLa cells assessed as decrease in SF3B1 phosphorylation at Thr434 after 48 hrs by Western blot analysis
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Target
Dual specificity protein kinase CLK4
(Mus musculus)
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 50nM
Assay Description:
Inhibition of mouse recombinant GST-tagged CLK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scin...
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT)
Universit£
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 56nM
Assay Description:
Inhibition of rat recombinant C-terminal truncated GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP ...
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 56nM
Assay Description:
Inhibition of human DYRK1A
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 57nM
Assay Description:
Inhibition of human DYRK1B using [33P]-ATP incubated for 120 mins
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 60nM
Assay Description:
Inhibition of human recombinant C-terminal truncated GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]AT...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 60nM
Assay Description:
Inhibition of DYRK1A (unknown origin)
More data for this Ligand-Target Pair
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Target
Dual specificity protein kinase CLK1
(Mus musculus)
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 72nM
Assay Description:
Inhibition of mouse recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scin...
More data for this Ligand-Target Pair
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Target
Dual specificity protein kinase CLK1
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 72nM
Assay Description:
Inhibition of CLK1 (unknown origin)
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Copy SMILES
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Affinity Data
IC50: 80nM
Assay Description:
Inhibition of Dyrk1A (unknown origin) using dynatide 3 as substrate after 10 mins by P81 membrane assay in presence of [33P]-g-ATP
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 80nM
Assay Description:
Inhibition of human DYRK1A kinase expressed in Escherichia coli cells
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 80nM
Assay Description:
Inhibition of human full length DYRK1A using KKISGRLSPIMTEQ as substrate after 30 mins in presence of [gamma33P-ATP]
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 80nM
Assay Description:
Inhibition of DYRK1A (unknown origin)
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 80nM
Assay Description:
Inhibition of DYRK1A (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assay
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 80nM
Assay Description:
Inhibition of DYRK1A in the presence of 50uM ATP
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 80nM
Assay Description:
Inhibition of DYRK1A (unknown origin)
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 85nM
Assay Description:
Inhibition of human recombinant full length GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 3...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 120nM
Assay Description:
Inhibition of human recombinant GST-tagged DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by sci...
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 130nM
Assay Description:
Inhibition of recombinant human N-terminal His6-tagged DYRK1A catalytic domain expressed in Escherichia coli BL21(DE3) cells using KKISGRLSPIMTEQ-NH2...
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 160nM
Assay Description:
Inhibition of recombinant GST-tagged DYRK1B (unknown origin) expressed in Escherichia coli using DYRKtide as substrate after 5 mins in presence of [g...
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 166nM
Assay Description:
Inhibition of GST-tagged Dyrk1B (unknown origin) expressed in Escherichia coli using [33P]ATP[gammaP]/DYRKtide as substrate after 5 mins by liquid sc...
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 180nM
Assay Description:
Inhibition of full length recombinant human GST-tagged DYRK1B expressed in insect cells using KKISGRLSPIMTEQ-NH2 as substrate incubated for 15 mins i...
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 200nM
Assay Description:
Inhibition of human DYRK1A-mediated tau phosphorylation expressed in HEK293 cells incubated for 2 hrs by ELISA
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 3
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 210nM
Assay Description:
Inhibition of human recombinant GST-tagged DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by sci...
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Target
Dual specificity protein kinase CLK1
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 220nM
Assay Description:
Inhibition of recombinant human GST-tagged CLK1 catalytic domain (129 to 484 residues) expressed in Escherichia coli using GRSRSRSRSRSRSRSR as substr...
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Dual specificity protein kinase CLK2
(Mus musculus)
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 280nM
Assay Description:
Inhibition of mouse recombinant GST-tagged CLK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scin...
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 400nM
Assay Description:
Inhibition of tetracycline-inducible EGFP-DYRK1A (unknown origin) expressed in HEK293 cells coexpressing full length human EGFP-tau protein assessed ...
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Dual specificity tyrosine-phosphorylation-regulated kinase 3
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 410nM
Assay Description:
Inhibition of full-length recombinant human GST-tagged DYRK3 expressed in Escherichia coli using woodtide as substrate after 30 mins in presence of [...
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Target
Serine/threonine-protein kinase haspin
(Homo sapiens (Human))
Harvard Medical School
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 590nM
Assay Description:
Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay
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Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 690nM
Assay Description:
Inhibition of DYRK2
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Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 700nM
Assay Description:
Inhibition of human recombinant full length GST-tagged DYRK1A expressed in baculovirus expression system assessed as decrease in tau phosphorylation ...
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Target
Cyclin-T1/Cyclin-dependent kinase 9
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 720nM
Assay Description:
Inhibition of human recombinant CDK9/cyclin T expressed in insect cell using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate and [gamma33P]ATP after 30 mins b...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 3
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 800nM
Assay Description:
Inhibition of human full length DYRK3 using KKISGRLSPIMTEQ as substrate after 30 mins in presence of [gamma33P-ATP]
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 3
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 800nM
Assay Description:
Inhibition of DYRK3 (unknown origin)
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 3
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 800nM
Assay Description:
Inhibition of DYRK3 in the presence of 50uM ATP
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 900nM
Assay Description:
Inhibition of DYRK2 in the presence of 50uM ATP
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 900nM
Assay Description:
Inhibition of DYRK2 (unknown origin)
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 900nM
Assay Description:
Inhibition of human full length DYRK2 using KKISGRLSPIMTEQ as substrate after 30 mins in presence of [gamma33P-ATP]
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nantong University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Inhibition of HDAC1 (unknown origin) using Boc-Lys (Ac)-AMC as substrate incubated for 60 mins by fluorimetric assay
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nantong University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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IC50: >1.00E+3nM
Assay Description:
Inhibition of HDAC1 (unknown origin) using Boc-Lys (Ac)-AMC as substrate incubated for 60 mins and measured after 30 mins by fluorescence assay
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Histone deacetylase 1
(Homo sapiens (Human))
Nantong University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Inhibition of HDAC1 (unknown origin)
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Casein kinase I isoform delta
(Homo sapiens (Human))
University Of Dundee
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 1.50E+3nM
Assay Description:
Inhibition of CK1delta in the presence of 20uM ATP
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Casein kinase I delta/epsilon
(Homo sapiens (Human))
Paris-Sud University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 1.50E+3nM
Assay Description:
Inhibition of CK1 delta/epsilon (unknown origin)
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of GST-tagged Dyrk2 (unknown origin) expressed in Escherichia coli using [33P]ATP[gammaP]/DYRKtide as substrate after 5 mins by liquid sci...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Inhibition of DYRK2 (unknown origin) using woodtide as substrate after 40 mins in presence of [gamma-33P]ATP by microbeta scintillation counting
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Inhibition of recombinant human N-terminal GST-tagged DYRK2 expressed in Escherichia coli BL21(DE3) cells using KKISGRLSPIMTEQ-NH2 as substrate incub...
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Serine/threonine-protein kinase pim-3
(Homo sapiens (Human))
University Of Dundee
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 4.30E+3nM
Assay Description:
Inhibition of PIM3 in the presence of 20uM ATP
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Broad substrate specificity ATP-binding cassette transporter ABCG2
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 5.08E+3nM
Assay Description:
Inhibition of human ABCG2 expressed in MDCK2 cells assessed as reduction in pheophorbide A efflux pre-incubated for 30 mins before Hoechst 33342 addi...
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Target
Chitinase
(Onchocerca volvulus)
The Scripps Research Institute
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 7.06E+3nM
Assay Description:
Inhibition of L3 larval stage of Onchocerca volvulus chitinase using 4-methylumbelliferyl-N-N'-N''-beta-chitotrioside as substrate assessed as releas...
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Target
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 8.00E+3nM
Assay Description:
Inhibition of human recombinant CDK5/p25 using histone H1 as substrate and [gamma33P]ATP after 30 mins by scintillation counting
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Dual specificity tyrosine-phosphorylation-regulated kinase 4
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 9.50E+3nM
Assay Description:
Inhibition of human recombinant GST-tagged DYRK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by sci...
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Target
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting
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Target
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human recombinant PIM1 expressed in Escherichia coli using histone H1 as substrate and [gamma33P]ATP after 30 mins by scintillation cou...
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human recombinant GSK3beta expressed in insect cells using YRRAAVPPSPSLSRHSSPHQ-phosphoS-EDEEE as substrate and [gamma33P]ATP after 30 ...
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Target
Glycogen synthase kinase-3 alpha
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human recombinant GSK3alpha expressed in insect cells using YRRAAVPPSPSLSRHSSPHQ-phosphoS-EDEEE as substrate and [gamma33P]ATP after 30...
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Target
Dual specificity protein kinase CLK3
(Mus musculus)
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of mouse recombinant GST-tagged CLK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scin...
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Cyclin-H/Cyclin-dependent kinase 7
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human recombinant CDK7/cyclin H expressed in insect cell using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate and [gamma33P]ATP after 30 mins b...
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Target
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of human recombinant CDK5/p25 using histone H1 as substrate after 30 mins in presence of [gamma-33 P] ATP by liquid scintillation counting...
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Glycogen synthase kinase-3
(Homo sapiens (Human))
Paris-Sud University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of GSK-3 alpha/beta (unknown origin)
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Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human))
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: <1.00E+4nM
Assay Description:
Inhibition of recombinant human CDK2/cyclin A using histone H1 as substrate after 30 mins in presence of ATP by scintillation counting method
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Target
Histone deacetylase
(Homo sapiens (Human))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys (Ac)-AMC as substrate after 60 mins by fluorometric analysis
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Target
Histone deacetylase
(Homo sapiens (Human))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of HDAC in human HeLa nuclear extract
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Acetylcholinesterase
(Electrophorus electricus (Electric eel))
Shenyang Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 1.01E+4nM
Assay Description:
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and m...
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Cholinesterase
(Equus caballus (Horse))
Shenyang Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 1.36E+4nM
Assay Description:
Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and ...
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Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3
(Homo sapiens (Human))
Institute Of Molecular And Cell Biology
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 1.80E+4nM
Assay Description:
Inhibition of Cell division cycle 2 (CDK1)-cyclin B
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Target
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 2.10E+4nM
Assay Description:
Inhibition of Cyclin-dependent kinase 5-p35nck5a
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Target
Acetylcholinesterase
(Electrophorus electricus (Electric eel))
Shenyang Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 2.29E+4nM
Assay Description:
Inhibition of electric eel AChE using acetylcholine iodide as substrate measured every 5 sec for 2 mins by Ellman's method
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Target
Mitogen-activated protein kinase 1
(Rattus norvegicus (rat))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >3.00E+4nM
Assay Description:
Inhibition of rat recombinant ERK2 using Ets1 as substrate and [gamma33P]ATP as substrate after 30 mins by scintillation counting
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 3.21E+4nM
Assay Description:
Inhibition of human full length GSK3beta expressed in baculovirus in Sf9 insect cells using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate by ADP-Glo kin...
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 3.21E+4nM
Assay Description:
Inhibition of GSK3-beta (unknown origin) incubated for 60 mins by ATP-Glo luminescent assay
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Target
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human))
Institute Of Molecular And Cell Biology
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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IC50: 3.50E+4nM
Assay Description:
Inhibition of Cyclin-dependent kinase 2-cyclin A
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of GSK3beta (unknown origin)
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 4
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 7.40E+4nM
Assay Description:
Inhibition of GST-tagged Dyrk4 (unknown origin) expressed in Escherichia coli using [33P]ATP[gammaP]/DYRKtide as substrate after 5 mins by liquid sci...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 4
(Homo sapiens (Human))
Cnrs
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: 8.00E+4nM
Assay Description:
Inhibition of full-length recombinant human GST-tagged DYRK4 expressed in baculovirus infected insect cells using DYRKtide as substrate after 5 mins ...
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Target
Tyrosine-protein kinase Fyn
(Homo sapiens (Human))
Institute Of Molecular And Cell Biology
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >2.50E+5nM
Assay Description:
Inhibition of Fyn kinase
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Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
Institute Of Molecular And Cell Biology
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >2.50E+5nM
Assay Description:
Inhibition of p56 Lck tyrosine kinase
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Target
O94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139
(Homo sapiens (Human))
Institute Of Molecular And Cell Biology
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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IC50: >2.50E+5nM
Assay Description:
Inhibition of protein kinase C
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Target
Tyrosine-protein kinase Lyn
(Homo sapiens (Human))
Institute Of Molecular And Cell Biology
Curated by
ChEMBL
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
IC50: >2.50E+5nM
Assay Description:
Inhibition of Lyn tyrosine kinase
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Target
Kallikrein-7
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
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Affinity Data
EC50: 2.48E+4nM
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