Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of the 5-hydroxytryptamine 1A receptor in rat dorsal rapheMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  700nMAssay Description:Inhibitory concentration of the compound required against 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory concentration required against Alpha-2 adrenergic receptor in rat cortex [3H]clonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory concentration required against alpha-1 adrenergic receptor in rat cortex using [3H]-WB- 4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory concentration of the compound required against 5-HT uptake in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibitory concentration of the compound required against Dopamine receptor D2 in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibitory concentration required against 5-hydroxytryptamine 2 receptor in rat cortex using [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration of the compound required against 5-hydroxytryptamine 1C receptor in bovine choroid plexus using [3H]-mesulergineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration of the compound required against 5-HT3 receptor in bovine area postrema using [3H]-GR 65630More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122411(1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-pi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration of the compound required against 5-hydroxytryptamine 1B receptor in rat striatum using [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed