Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetMitogen-activated protein kinase 1(Mus musculus (Mouse))
Merck Sharp & Dohme

US Patent

LigandBDBM50437408(CHEMBL2408790 | US9023865, 2)Copy SMILESCopy InChI

Affinity DataIC50:  0.152nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent

LigandBDBM50437408(CHEMBL2408790 | US9023865, 2)Copy SMILESCopy InChI

Affinity DataIC50:  0.286nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent

LigandBDBM50437408(CHEMBL2408790 | US9023865, 2)Copy SMILESCopy InChI

Affinity DataIC50:  0.286nMAssay Description:Inhibition of human ERK2 pre-incubation for 15 mins before substrate addition measured after 60 mins by IMAP-FP assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMitogen-activated protein kinase 1(Mus musculus (Mouse))
Merck Sharp & Dohme

US Patent

LigandBDBM157160(US9023865, 4)Copy SMILES

Affinity DataIC50:  1.12nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI

TargetMitogen-activated protein kinase 1(Mus musculus (Mouse))
Merck Sharp & Dohme

US Patent

LigandBDBM157159(US9023865, 3)Copy SMILES

Affinity DataIC50:  36.6nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI