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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
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Target
SUMO-conjugating enzyme UBC9
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM32317
(2-(8-methoxy-2-methyl-quinolin-4-yl)sulfanyl-N'-[(...)
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Affinity Data
IC50: 3.17E+3nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
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Target
SUMO-activating enzyme subunit 1
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM32317
(2-(8-methoxy-2-methyl-quinolin-4-yl)sulfanyl-N'-[(...)
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Affinity Data
IC50: 2.86E+4nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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antibodypedia
GoogleScholar
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Target
Bcl-2-like protein 2
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32317
(2-(8-methoxy-2-methyl-quinolin-4-yl)sulfanyl-N'-[(...)
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Affinity Data
EC50: 5.52E+4nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...
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Target Info
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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32317
(2-(8-methoxy-2-methyl-quinolin-4-yl)sulfanyl-N'-[(...)
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Affinity Data
EC50: 2.90E+4nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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antibodypedia
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Target
Glutathione S-transferase Mu 1
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32317
(2-(8-methoxy-2-methyl-quinolin-4-yl)sulfanyl-N'-[(...)
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Affinity Data
EC50: 4.54E+4nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-re...
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Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
Bcl-2-like protein 10 [11-204]
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32317
(2-(8-methoxy-2-methyl-quinolin-4-yl)sulfanyl-N'-[(...)
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Affinity Data
EC50: 9.13E+3nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...
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Target
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32317
(2-(8-methoxy-2-methyl-quinolin-4-yl)sulfanyl-N'-[(...)
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Affinity Data
EC50: 8.36E+4nM
pH: 7.4 T: 2°C
Assay Description:
The HTS assay was conducted in 384-well microplates in a total assay volume per well of 10.1 microliters (5 microliters of bead mixture, 0.1 microlit...
More data for this Ligand-Target Pair
Target Info
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Target
Apoptosis regulator Bcl-2
(Homo sapiens (Human))
Nmmlsc
Curated by
PubChem BioAssay
Ligand
BDBM32317
(2-(8-methoxy-2-methyl-quinolin-4-yl)sulfanyl-N'-[(...)
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Affinity Data
EC50: 2.41E+4nM
Assay Description:
University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
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