Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL

LigandBDBM50393614(CHEMBL2158529)Copy SMILESCopy InChI

Affinity DataIC50:  6nMAssay Description:Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetALK tyrosine kinase receptor/Nucleophosmin(Homo sapiens (Human))
Cephalon

Curated by ChEMBL

LigandBDBM50393614(CHEMBL2158529)Copy SMILESCopy InChI

Affinity DataIC50:  70nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetInsulin receptor(Homo sapiens (Human))
Cephalon

Curated by ChEMBL

LigandBDBM50393614(CHEMBL2158529)Copy SMILESCopy InChI

Affinity DataIC50:  222nMAssay Description:Inhibition of IRMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI