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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
19
hits in this display
Target
D(3) dopamine receptor
(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
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Affinity Data
Ki: 0.190nM
Assay Description:
Displacement of [125]IABN from human D3 receptor expressed in HEK293 cells
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
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Copy InChI
Affinity Data
Ki: 0.230nM
Assay Description:
Displacement of [3H]spiroperidol from human cloned dopamine D3 receptor by liquid scintillation counting
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.230nM
Assay Description:
Binding affinity for human Dopamine receptor D3 by [3H]- spiperone displacement.
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.270nM
Assay Description:
Displacement of [3H]Spiperone from human dopamine D3 receptor expressed in CHO cells
More data for this Ligand-Target Pair
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Copy SMILES
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Affinity Data
Ki: 15nM
Assay Description:
Binding affinity for human Dopamine receptor D4 by [3H]- spiperone displacement.
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
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Affinity Data
Ki: 25nM
Assay Description:
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cell membranes by radioligand competition binding assay
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
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Affinity Data
Ki: 41nM
Assay Description:
Displacement of [3H]- 8-OH-DPAT from porcine 5-hydroxytryptamine 1A receptor
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Copy SMILES
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Affinity Data
Ki: 52nM
Assay Description:
Binding affinity for human Dopamine receptor D2 (short) by [3H]- spiperone displacement.
More data for this Ligand-Target Pair
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 72nM
Assay Description:
Displacement of [3H]Spiperone from human dopamine D2 short receptor expressed in CHO cells
More data for this Ligand-Target Pair
Target Info
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 87nM
Assay Description:
Binding affinity for human Dopamine receptor D2 (long) by [3H]- spiperone displacement.
More data for this Ligand-Target Pair
Target Info
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 95nM
Assay Description:
Displacement of [3H]Spiperone from human dopamine D2 long receptor expressed in CHO cells
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Copy SMILES
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Affinity Data
Ki: 120nM
Assay Description:
Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK293 cell membranes by radioligand competition binding assay
More data for this Ligand-Target Pair
Target Info
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 305nM
Assay Description:
Displacement of [125]IABN from human D4 receptor expressed in HEK293 cells
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 2A
(PIG)
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
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Affinity Data
Ki: 350nM
Assay Description:
Displacement of [3H]Ketanserin from 5-HT2 receptor in pig cortex membranes
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
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Affinity Data
Ki: 670nM
Assay Description:
Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.
More data for this Ligand-Target Pair
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 800nM
Assay Description:
Displacement of [3H]SCH23390 from D1 receptor
More data for this Ligand-Target Pair
Target Info
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Target
D(1A) dopamine receptor
(Sus scrofa)
Friedrich-Alexander University
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 820nM
Assay Description:
Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes
More data for this Ligand-Target Pair
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
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Affinity Data
IC50: 0.220nM
Assay Description:
Antagonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of quinpirole-stimulated mitogenesis
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM50119386
(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 0.360nM
Assay Description:
Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cells
More data for this Ligand-Target Pair
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