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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
9
hits in this display
Target
Serine/threonine-protein kinase PLK3
(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by
ChEMBL
Ligand
BDBM50318081
(8-[(2-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H...)
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Affinity Data
IC50: 13nM
Assay Description:
Inhibition of Plk3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine/threonine-protein kinase PLK2
(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by
ChEMBL
Ligand
BDBM50318081
(8-[(2-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 24nM
Assay Description:
Inhibition of Plk2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by
ChEMBL
Ligand
BDBM50318081
(8-[(2-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 41nM
Assay Description:
Inhibition of CDK2/Cyclin A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by
ChEMBL
Ligand
BDBM50318081
(8-[(2-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 42nM
Assay Description:
Inhibition of GST-tagged PLK1 expressed in H5 insect cells assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by
ChEMBL
Ligand
BDBM50318081
(8-[(2-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 42nM
Assay Description:
Inhibition of PLK1 assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Dual specificity protein kinase TTK
(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by
ChEMBL
Ligand
BDBM50318081
(8-[(2-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 66nM
Assay Description:
Inhibition of MPS1 assessed as [33P]-gamma-ATP incorporation into substrate P38-betatide by gamma counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by
ChEMBL
Ligand
BDBM50318081
(8-[(2-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 90nM
Assay Description:
Inhibition of CDK2/Cyclin A assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Aurora kinase A
(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by
ChEMBL
Ligand
BDBM50318081
(8-[(2-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 607nM
Assay Description:
Inhibition of Aur-A assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Aurora kinase A
(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by
ChEMBL
Ligand
BDBM50318081
(8-[(2-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 607nM
Assay Description:
Inhibition of Aurora A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI