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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
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Target
Angiotensin-converting enzyme
(Homo sapiens (Human))
University Of Bath
Curated by
ChEMBL
Ligand
BDBM50085452
((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
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Affinity Data
Ki: 14nM
Assay Description:
Inhibition of human testis ACE C-domain lacking unique O-glycosylated region, transmembrane anchor and cytoplasmic tail expressed in CHO cells using ...
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Target Info
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KEGG
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3D Structure (crystal)
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Target
Angiotensin-converting enzyme
(Homo sapiens (Human))
University Of Bath
Curated by
ChEMBL
Ligand
BDBM50085452
((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
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Affinity Data
Ki: 172nM
Assay Description:
Inhibition of human somatic ACE N-domain soluble form (1 to 629 residues) expressed in CHO cells using Z-FHL as substrate preincubated with enzyme fo...
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Target Info
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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PubMed
PDB
3D Structure (crystal)
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Target
Neprilysin
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50085452
((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
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Affinity Data
IC50: 0.600nM
Assay Description:
Inhibition of neutral endopeptidase
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Natriuretic peptides A
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50085452
((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
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Affinity Data
IC50: 3.40nM
Assay Description:
Inhibition of atrial natriuretic peptide
More data for this Ligand-Target Pair
Target Info
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Target
Angiotensin-converting enzyme
(Oryctolagus cuniculus)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50085452
((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
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Affinity Data
IC50: 7nM
Assay Description:
Inhibition of Angiotensin I converting enzyme
More data for this Ligand-Target Pair
Target Info
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Target
Neprilysin
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50085452
((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
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Affinity Data
IC50: 8nM
Assay Description:
Inhibition of NEP (unknown origin)
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Target Info
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CHEMBL
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3D Structure (crystal)
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Target
Neprilysin
(Rattus norvegicus (Rat))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50085452
((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
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Affinity Data
IC50: 20nM
Assay Description:
Inhibition of Neutral endopeptidase
More data for this Ligand-Target Pair
Target Info
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Target
Endothelin-converting enzyme 1
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50085452
((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
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Affinity Data
IC50: 1.50E+3nM
Assay Description:
In vitro inhibition of phosphoramidon-sensitive membrane bound zinc metalloprotease Endothelin-converting enzyme from partially purified guinea pig l...
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Target Info
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